Caloric restriction : a key to understanding and modulating aging
For many years, it has been known that when rats and mice are given a reduced amount of food, their life span is increased and they remain healthy and vigorous at advanced ages. What is the reason for this change in the usual pattern of aging? The evidence is overwhelming that the life extension results from a slowing of aging processes. And the factor responsible is the decrease in caloric intake. The obvious question: How does this factor work? A good question - and the reason that research on the anti-aging action of caloric restriction is today one of the most studied research areas in biological gerontology. For it is felt that if the biological mechanisms of the anti-aging action of caloric restriction can be uncovered, we would gain an understanding of the basic nature of aging processes, which would, in turn, yield possible interventions in human aging. This book aims to provide the growing number of researchers in this field (faculty, postdoctoral trainees, and graduate students) with a detailed knowledge of what is known about caloric restriction within the frame of gerontology, as well as insights on future of this field
Internet Resources
1 online resource (vii, 183 pages) : illustrations
9780444511621, 9780080528427, 0444511628, 0080528422
162131265
Cover
Table of Contents
Preface
Chapter 1. Overview
Chapter 2. Mortality Characteristics
Chapter 3. Molecular and Cellular Biology
Chapter 4. Organismic Physiology
Chapter 5. Age-Associated Diseases
Chapter 6. Mechanisms of the Anti-Aging Action of Caloric Restriction
Chapter 7. Evolution of Anti-Aging Action of Caloric Restriction
Chapter 8. Caloric Restriction Mimetics
Index
Last Page