Bioimaging in neurodegeneration
New imaging sensors, molecular probes, and neuromarkers for faster temporal resolution, smaller spatial resolution, and higher anatomic accuracy have made brain neuroimaging highly valuable in studying neuropathologies. Provocative insights into how the human brain actually works in real time and in vivo are now possible. In Bioimaging in Neurodegeneration, prominent physicians, researchers, and inventors of cutting-edge technologies review the new imaging tools available for diagnosing, treating, and discovering the underlying causes of Parkinson's and Alzheimer's disease, epilepsy, and leukodystrophy. The new technologies demonstrated include novel sequences for magnetic resonance imaging (MRI), such as magnetization-prepared rapid acquisition gradient echo (MPRAGE); proton magnetic resonance spectroscopy (1H MRS); new tracers for positron emission tomography (PET) and single-photon emission tomography (SPECT), such as tropane analogs and altropane; neuromolecular imaging (NMI) of neurotransmitters directly in brain synapses of epilepsy patients with unique carbon-based electrochemical sensors; and intrinsic optical signal imaging (IOS), useful in diagnosing "spreading epileptiform depression." NMI and IOS also promise applications in intraoperative guided neurosurgery. Pediatric mitochondrial cytopathies are discussed, as well as nanotechnology, microtechnology, nanoimaging, and microimaging are presented. Devices for diagnosing tumors are also described. To enhance understanding of the potential of these developing technologies, a companion compact disk contains color versions of selected black-and-white illustrations used in the book. Authoritative and state-of-the art, Bioimaging in Neurodegeneration offers both the physician and researcher a critical survey of the best new technologies for studying neurodegeneration, as well as describing their optimal use in the diagnosis and treatment of specific neurodegenerative diseases
1 online resource (327 pages)
9781280359330, 9786610359332, 9781592598885, 1280359331, 6610359334, 1592598889
1126481788
Available in another form:
Parkinson's Disease
Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy in Parkinson's Disease
Positron Emission Tomography and Single-Photon Emission Tomography in the Diagnosis of Parkinson's Disease
Positron Emission Tomography in Parkinson's Disease
[123I]-Altropane SPECT
Positron Emission Tomography and Embryonic Dopamine Cell Transplantation in Parkinson's Disease
Alzheimer's Disease
Neurotoxicity of the Alzheimer's?-Amyloid Peptide
Functional Imaging and Psychopathological Consequences of Inflammation in Alzheimer's Dementia
Neurotoxic Oxidative Metabolite of Serotonin
Predicting Progression of Alzheimer's Disease With Magnetic Resonance
Stages of Brain Functional Failure in Alzheimer's Disease
Epilepsy
Neocortical Epilepsy
Pediatric Cortical Dysplasia
Bioimaging L-Tryptophan in Human Hippocampus and Neocortex
In Vivo Intrinsic Optical Signal Imaging of Neocortical Epilepsy
Intraoperative Magnetic Resonance Imaging in the Surgical Treatment of Epilepsy
Periodic Epileptiform Discharges Associated With Increased Cerebral Blood Flow
Imaging White Matter Signals in Epilepsy Patients
Leukodystrophy (White Matter) Diseases
Overview of the Leukoencephalopathies
Pyramidal Tract Involvement in Adult Krabbe's Disease
Imaging Leukodystrophies
Advanced Magnetic Resonance Imaging in Leukodystrophies
Childhood Mitochondrial Disorders and Other Inborn Errors of Metabolism Presenting With White Matter Disease
Mitochondrial Disease
English
link.springer.com Springer eBooks (Biomedical and Life Sciences 2005)