BiochemistryThis popular study guide and review provide a quick survey of the field of biochemistry, covering the essentials that students need to know. Includes board-type questions to give students experience for what they will encounter in actual examinations. The book is thoroughly revised and updated throughout, with much new material on cholesterol and steroid metabolism, nutrition and protein synthesis. In addition, the authors have included a unique cross-referencing system to the book's companion volume, Harvey and Champe's Lippincott's Illustrated Review of Pharmacology . Lecturers - Click here to order a FREE Review Copy of this title ! |
Contents
Protein Structure and Function | 1 |
AcidBase Properties of Amino Acids | 6 |
Other Applications of the HendersonHasselbalch Equation | 10 |
Structure of Proteins | 13 |
Secondary Structure of Proteins | 18 |
Tertiary Structure of Globular Proteins | 21 |
Quaternary Structure of Proteins | 22 |
Denaturation of Proteins | 23 |
Amino Acids Metabolism of Carbon Skeletons I Catabolism of the Carbon Skeletons of Amino Acids | 243 |
Role of Folic Acid in Amino Acid Metabolism | 250 |
Biosynthesis of Nonessential Amino Acids | 251 |
Metabolic Defects in Amino Acid Metabolism | 253 |
Conversion of Amino Acids to Specialized Products | 257 |
Creatine | 264 |
Synthesis of Histamine | 265 |
Catecholamines | 266 |
Globular and Fibrous Proteins | 25 |
Hemoglobinopathies | 34 |
Fibrous Proteins | 38 |
Enzymes | 47 |
Properties of Enzymes | 48 |
How Enzymes Work | 49 |
Factors Affecting Reaction Velocity | 51 |
MichaelisMenten Equation | 52 |
Inhibition of Enzyme Activity | 54 |
Regulation of Enzyme Activity | 56 |
Enzymes in Clinical Diagnosis | 58 |
Intermediary Metabolism | 61 |
ATP as an Energy Carrier | 64 |
Electron Transport Chain | 66 |
Oxidative Phosphorylation | 70 |
Basic Concepts of Metabolism | 75 |
Regulation of Metabolism | 78 |
Transduction by Intracellular Receptors | 79 |
Intracellular Messenger Systems | 80 |
Other Messenger Systems | 84 |
Glycolysis | 87 |
Transport of Glucose Into Cells | 88 |
Alternate Fates of Pyruvate | 93 |
Energy Yield of Glycolysis | 95 |
Clinical Notes | 96 |
Hormonal Regulation of Glycolysis | 97 |
Gluconeogenesis | 99 |
Substrates for Gluconeogenesis | 102 |
Citric Acid Cycle | 105 |
Stoichiometry of the Citric Acid Cycle | 108 |
Regulation of the Citric Acid Cycle | 109 |
Hexose Monophosphate Pathway | 111 |
Nonoxidative Reactions | 113 |
Glucose 6Phosphate Dehydrogenase Deficiency | 115 |
Carbohydrate Metabolism | 119 |
Structure of Monosaccharides | 120 |
Reactions Involving Monosaccharides | 121 |
Digestion of Carbohydrates | 123 |
Glycogen Metabolism | 135 |
Glycosaminoglycans | 147 |
Glycoproteins | 157 |
Lipid Metabolism | 163 |
Fatty Acid and Triacylglycerol Metabolism | 171 |
Phospholipid Metabolism | 191 |
Glycolipid Metabolism | 199 |
Synthesis of Glycosphingolipids | 201 |
Sphingolipidoses | 202 |
Cholesterol and Steroid Metabolism | 205 |
Structure of Cholesterol | 206 |
Degradation of Cholesterol | 210 |
Plasma Lipoproteins | 213 |
Steroid Hormones | 222 |
Nitrogen Metabolism | 229 |
Digestion of Dietary Proteins | 231 |
Transport of Amino Acids Into Cells | 233 |
Urea Cycle | 236 |
Metabolism of Ammonia | 239 |
Melanin | 267 |
Integration of Metabolism | 269 |
Glucagon | 275 |
Hypoglycemia | 277 |
Metabolism in the WellFed State | 281 |
Nutrient Distribution Center | 283 |
Energy Storage Depot | 286 |
Skeletal Muscle | 287 |
Brain | 288 |
Summary of Absorptive State | 289 |
Metabolism in Starvation Diabetes Mellitus and Injury | 291 |
Liver in Starvation | 292 |
Adipose Tissue in Starvation | 293 |
Skeletal Muscle in Starvation | 294 |
Overview of Diabetes Mellitus | 295 |
NonInsulinDependent Diabetes | 299 |
Chronic Effects of Diabetes | 300 |
Nutrition | 303 |
Energy Requirements in Humans | 304 |
Macronutrients | 305 |
Minerals | 309 |
Dietary Recommendations | 311 |
Nutrition and Chronic Disease | 312 |
ProteinCalorie Malnutrition | 316 |
Vitamins I Overview | 319 |
WaterSoluble Vitamins | 321 |
FatSoluble Vitamins | 330 |
Storage and Expression of Genetic Information | 343 |
De Novo Purine Nucleotide Synthesis | 345 |
Salvage Pathway for Purines | 348 |
Pyrimidine Synthesis | 351 |
Degradation of Pyrimidine Nucleotides | 353 |
Synthesis of Thymidine Monophosphate From dUMP | 355 |
DNA Structure and Replication | 357 |
Steps in Prokaryotic DNA Synthesis | 361 |
Organization of Eukaryotic DNA | 371 |
DNA Repair | 372 |
RNA Structure and Synthesis | 377 |
Structure of RNA | 378 |
Transcription of Prokaryotic Genes | 379 |
Transcription of Eukaryotic Genes | 383 |
PostTranscriptional Modification of RNA | 385 |
Protein Synthesis | 389 |
Components Required for Translation | 391 |
Codon Recognition by tRNA | 394 |
PostTranslational Modification of Polypeptide Chains | 398 |
Molecular Basis of Inherited Disease | 401 |
Cleavage of DNA Into Fragments | 403 |
DNA Cloning | 404 |
Polymerase Chain Reaction | 407 |
Probes | 409 |
Southern Blotting | 411 |
Restriction Fragment Length Polymorphism | 413 |
Prenatal Diagnosis | 415 |
Index | 421 |
Copyright | |