Principles of Molecular CardiologyMarschall S. Runge, Cam Patterson An easy-to-read survey of all the latest developments in molecular cardiologic research and therapy. The authors explain in a readable style the complex process of the heart's development, the molecular basis of cardiovascular diseases, and the translation of these research advances to actual clinical treatments. The expert information provided here serves as an invaluable building block for novel treatments of cardiovascular diseases and includes a comprehensive discussion of cardiac function and dysfunction, coronary artery disease, cardiac arrhythmias, vascular diseases, and risk factors for cardiovascular disease. These state-of-the-art approaches to molecular cardiologic research include critical discussion of such topics as the molecular events that regulate angiogenesis and the potential for angiogenic therapy, emerging therapies for arrhythmias, and a description of the molecular biology of aging and its impact on the cardiovascular system. |
Contents
| 11 | |
Genomics and Its Application to Cardiovascular Disease | 45 |
Gene Therapy and Cardiovascular Diseases | 57 |
Stem Cells and Progenitor Cells in Cardiovascular Disease | 71 |
Development of the Vertebrate Heart | 83 |
Inherited Myocardial Diseases | 105 |
ReceptorSignaling Pathways in Heart Failure | 123 |
Recent Insights into the Molecular Pathophysiology of Viral Myocarditis | 145 |
Gene Therapy for Cardiac Arrhythmias | 353 |
Genetics and Arrhythmias | 359 |
Therapeutic Angiogenesis for Ischemic Vascular Disease | 369 |
Nitric Oxide in Cardiovascular Biology and Pathophysiology | 387 |
Vasculitis | 399 |
Primary Pulmonary Hypertension | 413 |
The Molecular Basis of Cerebrovascular Malformations | 437 |
Thrombotic Vascular Disease | 451 |
Genetic Underpinnings of Cardiogenesis and Congenital Heart Disease | 155 |
Coronary Artery Development | 167 |
Atherosclerosis | 185 |
Antiplatelet Drugs | 203 |
Myocardial Infarction | 219 |
Scientific Basis for Current Therapy | 271 |
Coronary Restenosis | 291 |
Induction and Patterning of Purkinje Fiber Network | 311 |
Mechanisms of Sudden Cardiac Death | 323 |
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abnormalities Acad Sci USA acid acute angiogenesis antibodies apoptosis arrhythmias associated atherosclerosis binding Biol Chem blood cardiac cardiomyopathy cellular cholesterol Circ Res Circulation Clin Invest clinical cloning Coll Cardiol coronary artery cytokines diabetes dilated effects embryonic endothelial cells endothelium Engl enzyme expression fibrinolysis formation function gene transfer genetic genome GP IIb/IIIa growth factor heart failure human hypertrophic cardiomyopathy hypertrophy increased induced inhibition inhibitor insulin integrin ischemia ischemic kinase left ventricular lesions levels lipid lipoprotein macrophages mechanisms mice molecular molecules monocytes mouse mutations myocardial infarction myocardium myocytes Natl Acad Sci neointimal nitric oxide pathway patients phenotype plasma plasmin plasminogen plasminogen activator platelet polymorphism Proc Natl Acad proliferation protein pulmonary hypertension Purkinje fibers receptor reduced remodeling restenosis risk factors role sequence signaling SMCs smooth muscle cells studies syndrome target therapy thrombin thrombosis tion tissue transcription transgenic trial vascular vectors VEGF vessel vivo