Principles of Molecular Cardiology

Front Cover
Marschall S. Runge, Cam Patterson
Springer Science & Business Media, Nov 14, 2007 - Medical - 617 pages
An easy-to-read survey of all the latest developments in molecular cardiologic research and therapy. The authors explain in a readable style the complex process of the heart's development, the molecular basis of cardiovascular diseases, and the translation of these research advances to actual clinical treatments. The expert information provided here serves as an invaluable building block for novel treatments of cardiovascular diseases and includes a comprehensive discussion of cardiac function and dysfunction, coronary artery disease, cardiac arrhythmias, vascular diseases, and risk factors for cardiovascular disease. These state-of-the-art approaches to molecular cardiologic research include critical discussion of such topics as the molecular events that regulate angiogenesis and the potential for angiogenic therapy, emerging therapies for arrhythmias, and a description of the molecular biology of aging and its impact on the cardiovascular system.
 

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Contents

Gene Therapy and Cardiovascular Diseases
57
Stem Cells and Progenitor Cells in Cardiovascular Disease
71
Development of the Vertebrate Heart
83
Inherited Myocardial Diseases
105
ReceptorSignaling Pathways in Heart Failure
123
Recent Insights into the Molecular Pathophysiology of Viral Myocarditis
145
Genetic Underpinnings of Cardiogenesis and Congenital Heart Disease
155
Coronary Artery Development
167
Gene Therapy for Cardiac Arrhythmias
353
Genetics and Arrhythmias
359
Therapeutic Angiogenesis for Ischemic Vascular Disease
369
Nitric Oxide in Cardiovascular Biology and Pathophysiology
387
Vasculitis
399
Primary Pulmonary Hypertension
413
The Molecular Basis of Cerebrovascular Malformations
437
Thrombotic Vascular Disease
451

Atherosclerosis
185
Antiplatelet Drugs
203
Myocardial Infarction
219
Scientific Basis for Current Therapy
271
Induction and Patterning of Purkinje Fiber Network
311
Mechanisms of Sudden Cardiac Death
323
RISK FACTORS
458
From Molecular to Clinical Cardiology
517
An Important Cardiovascular Risk Factor
563
Vascular Inflammation as a Cardiovascular Risk Factor
577
Index
605
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