Robbins Pathologic Basis of DiseasePresenting the latest edition of this popular, comprehensive and practical text of pathology. Written with great clarity for easy readability, this reference offers detailed discussions of genetic disorders, cellular injury and death, neoplasia, the skeletal system and soft tissue tumors, and much more. Completely revised and updated, this edition is even more user-friendly with the use of text boxes for key topics in each chapter and a new full-color design. Features 1200 excellent 4-color illustrations! |
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Page 178
... normal and all females are carriers . During oogenesis in the carrier female , premutation expands to full mutation ... Normal Normal Normal CARRIER FEMALE & CARRIER FEMALE UNRELATED 8 52 X Chromosomes Phenotype Normal Normal Normal ...
... normal and all females are carriers . During oogenesis in the carrier female , premutation expands to full mutation ... Normal Normal Normal CARRIER FEMALE & CARRIER FEMALE UNRELATED 8 52 X Chromosomes Phenotype Normal Normal Normal ...
Page 183
... ( normal ) oligonucleotide probe Z oligonucleotide probe Normal. 67 bp - 37 bp- 163 bp NORMAL 5 ' 3 ' Mutation PCR primer MUTANT 5 ' H 67 bp Mutant 200 67 163 15132 67 37 200 bp Normal Heterozygote 200 163 132 67 37 PCR primer 3 ' Figure 6 ...
... ( normal ) oligonucleotide probe Z oligonucleotide probe Normal. 67 bp - 37 bp- 163 bp NORMAL 5 ' 3 ' Mutation PCR primer MUTANT 5 ' H 67 bp Mutant 200 67 163 15132 67 37 200 bp Normal Heterozygote 200 163 132 67 37 PCR primer 3 ' Figure 6 ...
Page 184
... ( normal ) oligonucleotide probe Z oligonucleotide probe Normal allele Mutant allele PCR primers PKD gene Schematic diagram. A. HYBRIDIZATION ACCATCGACGACAAAGGGA Strong Normal gene Weak ACCATCGACAACAAAGGGA Strong Mutant gene B. Primers ...
... ( normal ) oligonucleotide probe Z oligonucleotide probe Normal allele Mutant allele PCR primers PKD gene Schematic diagram. A. HYBRIDIZATION ACCATCGACGACAAAGGGA Strong Normal gene Weak ACCATCGACAACAAAGGGA Strong Mutant gene B. Primers ...
Contents
Acute and Chronic Inflammation | 50 |
Cellular Growth Fibrosis | 89 |
Hemodynamic Disorders Thrombosis | 113 |
Copyright | |
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abnormal acid activation acute adhesion allele amyloidosis antibodies antigens apoptosis arteries associated atherosclerosis bacterial benign binding blood cancer carcinoma cause CD4+ cell cycle cell death cellular Chapter chromosome chronic clinical collagen colon common complex cyclin cytokines damage defects deficiency develop disease disorders DNA repair edema effects endothelial cells endothelium enzymes epithelial example fibrosis Figure function gene genetic growth factors host human hypertension immune increased induced infection inflammation inflammatory integrins intracellular involved kinase lesions leukemia leukocytes lipid liver lung lymph nodes lymphocytes lymphoma lysosomal macrophages malignant mechanisms mediators membrane metabolism molecular molecules MORPHOLOGY mutations necrosis neoplasms neutrophils normal occur oncogenes organs oxidative pathogenesis Pathology pathway patients plasma platelet produce proliferation protein protooncogenes pulmonary reaction receptor regulate renal respiratory response result risk signals skin smooth muscle surface syndrome synthesis T-cell tion tissue toxic transcription tumor tumor cells vascular vasculitis vessels viral virus viruses vitamin