Anaphylaxis and Hypersensitivity ReactionsMariana C. Castells Despite wide recognition as a serious public health problem, anaphylaxis and hypersensitivity reactions remain under-recognized and under-diagnosed. This book fills the gaps in our understanding of the identification of triggers, recognition of clinical presentations, understanding of the natural history of these reactions, and selection of treatment strategies including those focused on cellular and molecular targets. The book provides a detailed examination of disease etiology, pathogenesis, and pathophysiology and their correlation to clinical practice. Forefront knowledge of the mediators and mechanisms of anaphylaxis is covered with an emphasis on how new discoveries shape our current and emerging therapies. |
Contents
| 1 | |
| 13 | |
Pathophysiology and Organ Damage in Anaphylaxis | 33 |
Mast Cells Effector Cells of Anaphylaxis | 47 |
Basophils in Anaphylaxis | 69 |
Protease Mediators of Anaphylaxis | 89 |
Aspirin and NSAID Reactions Diagnosis Pathophysiology and Management | 107 |
IgEDependent and Independent Effector Mechanisms in Human and Murine Anaphylaxis | 127 |
Idiopathic Anaphylaxis | 223 |
ExerciseInduced Anaphylaxis and FoodDependent ExerciseInduced Anaphylaxis | 235 |
Mastocytosis and Mast Cell Activation Syndromes Presenting as Anaphylaxis | 245 |
Anaphylaxis in Mastocytosis | 257 |
Flushing and Urticarial Syndromes Presenting as Anaphylaxis | 271 |
Pharmacologic Management of Acute Anaphylaxis | 285 |
Drug Desensitizations in the Management of Allergy and Anaphylaxis to Chemotherapeutic Agents and Monoclonal Antibodies
| 297 |
Rapid Desensitizations for AntibioticInduced Hypersensitivity Reactions and Anaphylaxis | 313 |
FoodInduced Anaphylaxis | 145 |
AntibioticInduced Anaphylaxis | 171 |
Anaphylaxis During Radiological Procedures and in the Perioperative Setting | 183 |
HymenopteraInduced Hypersensitivity Reactions and Anaphylaxis | 209 |
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Common terms and phrases
activation acute administration agents allergen allergic reactions Allergy Clin Immunol anaphylactic reactions anaphylaxis angioedema antibiotics antibodies antigen appears aspirin associated basophils blood cause challenge chymase clinical considered contrast cutaneous death decreased degranulation demonstrated desensitization diagnosis disease dose drug effects epinephrine episodes et al evidence exposure expression factor fatal flushing food allergy function histamine human hypersensitivity reactions idiopathic anaphylaxis IgE-mediated immediate immune immunotherapy important increased induced initial injection involved lead less levels major mast cell activation mast cells mastocytosis mechanisms mediators medications mice mouse murine myocardial infarction observed occur oral pathway patients peanut potential present production protein protocol rapid recent receptors release reported response risk role sensitivity serum severe shock skin testing specific sting subjects suggest symptoms syndrome systemic Table therapy tion tissue tolerance treatment trigger tryptase urticaria venom