WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues

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International Agency for Research on Cancer, 2008 - Medical - 439 pages
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WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue is the third volume in the new WHO series on histological and genetic typing of human tumors. This authoritative, concise reference book covers the entire range of leukaemias and lymphomas. It provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome. Diagnostic criteria, pathological features, and associated genetic alterations are described in a strictly disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, incidence, age and sex distribution, location, clinical signs and symptoms, pathology, genetics, and predictive factors.

The book, prepared by 130 authors from 22 countries, contains more than 1,000 color photographs, numerous magnetic resonance and ultrasound images, CT scans, charts, and 2,500 references.

This book is in the series commonly referred to as the "Blue Book" series.

Contributors:Dr Cem Akin, Dr Loannis Anagnostopoulos, Dr Katsuyuki Aozasa, Dr Daniel A. Arber, Dr Michele Baccarani, Dr Barbara J. Bain, Dr Giovanni Barosi, Dr Lrith Baumann, Dr Marie-Christine Bene, Dr Daniel Benharroch, Dr John M. Bennett, Dr Francoise Berger, Dr Emillo Berti, Dr Gunnar Birgegard, Dr Clara D. Bloomfield, Dr Bettina Borisch, Dr Michael J. Borowitz, Dr Richard D. Brunning, Dr Walter Burgdorf, Dr Elias Campo, Dr Daniel Catovsky, Dr Lorenzo Cerroni, Dr Ethel Cesarman, Dr Amv Chadburn, Dr John K.C. Chan, Dr Wing Chung Chan, Dr Andreas Chott, Dr Robert W. Coupland, Dr Daphne De Jong, Dr Christiane De Wolf-Peeters, Dr Martina Deckert, Dr Jan Delabie, Dr Georges Delsol, Dr Ahmet Dogan, Dr Lyn M. Duncan, Dr Kojo S.J. Elenitoba-Johnson, Dr Luis Escribano, Dr Fabio Facchetti, Dr Brunangelo Falini, Dr Judith A. Ferry, Dr Christopher D.M. Fletcher, Dr Katheryn Foucar, Dr Randy D. Gascoyne, Dr Kevin C. Gatter, Dr Norbert Gattermann, Dr Phillippe Gaulard, Dr Ulrich Germing, Dr D. Gary Gilliland, Dr Heinz Gisslinger, Dr Peter L. Greenberg, Dr Thomas M. Grogan, Dr. Karen L. Grogg, Dr Margarita Guenova, Dr Nancy Lee Harris, Dr Robert Paul Hasserjian, Dr Eva Hellstrom-Lindberg, Dr Hans-Peter Horny, Dr Peter G. Isaacson, Dr Elaine S. Jaffe, Dr Ronald Jaffe, Dr Daniel M. Jones, Dr Marshall E. Kadin, Dr Masahiro Kikuchi, Dr Hiroshi Kimura, Dr Marsha C. Kinney, Dr Phillip M. Kluin, Dr Young-Hyeh Ko, Dr Alla M. Kovrigina, Dr Laszlo Krenacs, Dr W. Michael Kuehl, Dr Jeffery L. Kutok, Dr Hans Michael Kvasnicka, Dr Robert A. Kyle, Dr Richard A. Larson, Dr Michelle M. Le Beau, Dr Lorenzo Leoncini, Dr Alan F. List, Dr Kenneth A. Maclennan, Dr William R. Macon, Dr David Y. Mason, Dr Estella Matutes, Dr Robert W. Mckenna, Dr Chris J.L.M. Meijer, Dr Junia V. Melo, Dr Dean D. Metcalfe, Dr Manuela Mollejo, Dr Peter Moller, Dr Emilli Montserrat, Dr William G. Morice, Dr Hans Konrad Muller-Hermelink, Drshigeo Nakamura, Dr Bharat N. Nathwani, Dr Charlotte M. Niemeyer, Dr Hiroko Ohgaki, Dr Kiochi Ohshima, Dr Mihaela Onciu, Dr Atillio Orazi, Dr German Ott, Dr Marco Paulli, Dr Suat-Cheng Peh, Dr Loann Peterson, Dr Tony Petrella, Dr Stefano A. Pileri, Dr Miguel A. Piris, Dr Stefania Pittaluga, Dr Maurillio Ponzoni, Dr Sibrand Poppema, Dr Anna Porwit, Dr Leticia Quintanilla-Martinez, Dr Elisabeth Ralfiaker, Dr Martine Raphael, Dr Jonathan Said, Dr Christian A. Sander, Dr Masao Seto, Dr Kevin Shannon, Dr Bruce R. Smoller, Dr Ivy Sng, Dr Dominic Spagnolo, Dr Harald Stein, Dr Christer Sundstrom, Dr Steven H. Swerdlow, Dr Ayalew Tefferi, Dr Catherine Thieblemont, Dr Jurgen Thiele, Dr Peter Valent, Dr J.H. Van Krieken, Dr James W. Vardiman, Dr Beatrice Vergier, Dr Neus Villamor, Dr Reinhard Von Wasielewski, Dr Roger A. Warnke, Dr Steven A. Webber, Dr Dennis D. Weisenburger, Dr Lawrence M. Weiss, Dr Sean J. Whittaker, Dr Rein Willemze, Dr Wyndham H. Wilson, Dr Tadashi Yoshino

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Contents

WHO Classification
11
WHO Classification of tumours of haematopoietic
14
Introduction and overview of the classification
17
Chronic myelogenous leukaemia Refractory cytopenia with unilineage dysplasia
23
Myeloid and lymphoid neoplasms with
26
Polycythaemia vera 99503
43
Myeloproliferative neoplasm unclassifiable 99753
64
with PDGFRB rearrangement 99663
70
Precursor lymphoid neoplasms
170
Mature Bcell neoplasms 179 Enteropathyassociated Tcell lymphoma
289
Plasma cell neoplasms 200 Peripheral Tcell lymphoma NOS
312
Intravascular large Bcell lymphoma 252 mononucleosislike PTLD
345
Mature T and NKcell neoplasms 269 Follicular dendritic Cell Sarcoma
363
149
383
MYELODYSPLASTICMYELOPROLIFERATIVE AML with inv3q21q26
388
Chronic myelomonocytic leukaemia 99 453 AML megakaryoblastic
430

Acute undifferentiated leukaemia
150
Introduction and Overview of the classification
160
Myelodysplasticmyeloproliferative neoplasm
436
Copyright

About the author (2008)

The International Agency for Research on Cancer (IARC) is part of the World Health Organization. IARC's mission is to coordinate and conduct research on the causes of human cancer, the mechanisms of carcinogenesis, and to develop scientific strategies for cancer control. The Agency is involved in both epidemiological and laboratory research and disseminates scientific information through publications, meetings, courses, and fellowships.

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