The Practice of Medicinal Chemistry
Camille Georges Wermuth
Academic Press, May 2, 2011 - Science - 982 pages
The Practice of Medicinal Chemistry fills a gap in the list of available medicinal chemistry literature. It is a single-volume source on the practical aspects of medicinal chemistry. Considered ""the Bible"" by medicinal chemists, the book emphasizes the methods that chemists use to conduct their research and design new drug entities. It serves as a practical handbook about the drug discovery process, from conception of the molecules to drug production.
The first part of the book covers the background of the subject matter, which includes the definition and history of medicinal chemistry, the measurement of biological activities, and the main phases of drug activity. The second part of the book presents the road to discovering a new lead compound and creating a working hypothesis. The main parts of the book discuss the optimization of the lead compound in terms of potency, selectivity, and safety.
The Practice of Medicinal Chemistry can be considered a ""first-read"" or ""bedside book"" for readers who are embarking on a career in medicinal chemistry.
NEW TO THIS EDITION:
* Focus on chemoinformatics and drug discovery
* Enhanced pedagogical features
* New chapters including:
- Drug absorption and transport
- Multi-target drugs
* Updates on hot new areas:
NEW! Drug discovery and the latest techniques
NEW! How potential drugs can move through the drug discovery/ development phases more quickly
Lead Compound Discovery Strategies
Primary Exploration of StructureActivity Relationships
Substituents and Functions Qualitative and Quantitative Aspects of StructureActivity Relationships
Spatial Organization Receptor Mapping and Molecular Modeling
3D QSAR affinity agents agonists analogs analysis approach assay atoms binding bioactive biochemical bioisosteres biological activity cancer carboxylic cell Chem chemical space chemists clinical combinatorial complex compounds computational conformational crystal Curr database derivatives descriptors disease DMLs dopamine drug design Drug Discov drug discovery drug targets drug-like druggable effects enantiomers enzyme epothilone example Figure fragment functional gene genome GPCRs high-throughput high-throughput screening histamine human hydrogen bond hydrophobic identified inhibition inhibitors interactions isosteric kinase lead libraries ligand lipophilic medicinal chemistry metabolism methods methyl molecular molecules natural products novel optimization oral peptide Pharm pharmaceutical Pharmacol pharmacological pharmacophore pharmacophore model potent prediction properties protein QSAR racemic receptor antagonists ring scaffold selective similar small molecule solubility structure structure-based structure–activity studies substituents synthesis synthetic therapeutic tion toxicity treatment twin drugs virtual screening vitro vivo X-ray