Medicinal Natural Products: A Biosynthetic ApproachMedicinal Natural Products, Second Edition is a comprehensive guide providing information on all classes of natural products in medicine. It builds upon fundamental chemical principles and demonstrates a unique integration of plant, microbial and animal natural products in one volume. The text guides the reader through a wealth of diverse natural metabolites used in medicine with sources, production methods, use as drugs and modes of action all extensively covered. Taking a chemistry based approach it combines traditional pharmacognosy with medicinal chemistry. The structure is user-friendly and includes the acclaimed grey boxes on groups of products and detailed mechanistic explanations. * Adopts a novel biosynthetic theme rather than a traditional descriptive approach * Includes extensive further reading at the end of the chapter * Thoroughly revised and updated to incorporate comprehensive coverage of plant, microbial and animal products * Includes the latest developments in the field * New material on genetic manipulation of biosynthetic pathways and non-mevalonate pathway to terpanoids * User-friendly format including extensive use of chemical schemes with annotated mechanistic explanations |
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Contents
ABOUT THIS BOOK AND HOW TO USE | 1 |
THE BUILDING BLOCKS AND CONSTRUCTION | 7 |
Some Vitamins Associated with the Construction Mechanisms | 30 |
Copyright | |
20 other sections not shown
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Common terms and phrases
4th edn acetate acetyl-CoA acid Figure activity aflatoxin agents alcohol aldehyde aldol alkaloids alkylation allylic amino acid analogues antibiotics aromatic ring bacteria biosynthesis carbocation carbon carbonyl cation cell Chem Chemical Technology cholesterol chorismic acid cinnamic acid Claisen cleavage CO2H CO2H coenzyme compounds contain Continues)_ cyclization decarboxylation derived diphosphate double bond drug Encyclopedia of Chemical enolization enzyme epoxide ester fatty acids formation function give glycosides H OH HO2C hormone hydrolysis hydroxylation inhibit inhibitors intermediate involved Kirk—Othmer lactone lignans macrolide malonyl-CoA metabolism metabolites methyl Module molecules NADPH Nat Prod Rep natural products nucleophilic nucleophilic attack oestrogen OH OH OH oxidation oxygen peptide phenol plants polyketide precursor produced prostaglandins protein proton reaction reduction residues rifamycin ring system SCoA SEnz sequence side-chain skeleton species starter steroid Streptomyces structures substituent substrate synthase synthesis T(Continued terpenoid tion toxic treatment units vitamin whilst

