variation in the amount given to any individual occurred it is noted by appropriate references in the table itself. Under the head "Special series" is a record of the amounts given to two of the original members of the table, who, by reason of illness other than that due to the administration of the preservative, were found unable to continue the regular course of experimental work. It was thought, however, that it would be of use to administer very small quantities of the preservative to these individuals throughout a long period of time in order to ascertain, if possible, by such an administration, any visible effect which this long-continued use of the preservative might produce. It is believed that the following data are sufficiently detailed to answer all purposes for reference and particular study. 1 1 1 1 1 Method of administration. No. 1. No. 2. No. 3. No. 4. No. 5. No. 6. No. 7. No. 8. No. 9. No. 10. No. 11. No. 12. No. 13. No. 14. TABLE II.-Schedule of administration of boric acid and borax. [Quantities expressed in terms of boric acid.] Grams. Grams. Grams. Grams. Grams. Grams. Grams. Grams. Grams. Grams. Grams. Grams. Grams. Grams. 1 1 1 1 1 Date. 123451 10 000000 1 quantity). 27-30, inclusive (daily quan tity). Jan. 28-31, inclusive (daily quan do tity). a Boric acid was administered to all subjects in Series I, II, and III, and borax to all in Series IV. In Series V, Nos. 1, 2, 3, and 12 received boric acid, Nos. 4, 5, 6, and 14 borax. In the special series boric acid was administered to both men. b About 4 grams given subject outside of Department. No. 10 having taken the full amount up tothe 10th, no preservative was given him in this period. Grams. Grams. Grams. Grams. Grams. Grams. Grams. Grams. Grams. Grams. Grams. Grams. Grams. Grams. 4 4 TABLE II.-Schedule of administration of boric acid and borax-Continued. Date. Method of administration. No. 1. No. 2. No. 3. No. 4. No. 5. No. 6. No. 7. No. 8. No. 9. No. 10. No. 11. No. 12. No. 13. No. 14. Series III-Continued. 0012300 00 00 4 .do 62 b Subject ill; quantity reduced. eSubject ill; no preservative given. d Resigned from table. e In Series V one-half gram of boric acid or its equivalent in borax was administered daily. No preservative was given to the following subjects on the days mentioned: No. 2, after June 11 (ill); No. 4, after May 25 (resigned); No. 5, on May 27 (ill), No. 6, on May 8 and 9 and after June 11 (ill); No. 12, on May 13 and June 16 (ill); No. 14. on May 4 and 13 and June 9 (ill). Total a Double portion given. EXCRETION OF THE BORIC ACID AND BORAX. Whether the preservative be given in the form of boric acid or borax appears to have little effect upon the percentage thereof appearing in the urine. In Tables III to VIII are found a detailed statement of the quantity of the preservative daily given in the food, in terms of boric acid, and the amount recovered in the urine, together with a statement of the total amount taken during the series, and the percentage of the total exhibited amount recovered in the urine. In Series I (Table III) it is seen that of 25 grams of boric acid taken by No. 1, 86.96 per cent is recovered in the urine. In the case where 1 gram is given, the first day 604.9 milligrams are recovered; on the second day, when the same amount is given, 871.3 milligrams are recovered; on the third day, when still the same amount is given, 902.8 milligrams are recovered; on the fourth day, when the maximum amount is recovered during the exhibition of 1 gram, 938.7 milligrams are recovered. It is apparent that there is a continued accumulation of boric acid in the system up to about the fourth day, when the quantities recovered in the urine remain almost constant. On the cessation of the administration of the boric acid the quantity in the urine rapidly falls. At the end of about the third or fourth day thereafter there are no longer any measurable quantities found, but traces of the preservative remain in the urine for about eight days. It may be said, then, without expressing the fact accurately for every case, that in about eight days after the cessation of the giving of large quantities of boric acid all traces of it are removed from the urine and presumably from the system. It will not be necessary to go over the data for each of the members of the table separately. They practically illustrate the principle which is outlined by the detailed data of No. 1. The largest percentage of the total exhibited amount recovered in the urine is found in the case of No. 2, namely, 88.51, and the smallest in the case of No. 5, 77.86. The average quantity excreted in the urine for the whole number under observation during the whole of the first series is 83.05 per cent. In Table IV are given the details of the exhibition of the preservative in Series II, with the quantities recovered. As has already been intimated, there are very serious irregularities in this table due to illness. Especially are the data for Nos. 8, 9, and 11 extremely unsatisfactory. In the case of No. 9 only 3 grams are given, excluding the quantity administered in the supplementary period, and in the case of No. 11 only 8 grams. Nos. 7 and 10 are the only members of the class who receive the full amount. The percentage eliminated in the urine of No. 7 is 81.82, and of No. 10, 82.13. The average amount eliminated in the urine for the whole class is 82.85 per cent. The data for Series III are given in Table V. The data for this series are also incomplete, and especially do they vary from the other |