Chirality in Industry II: Developments in the Commercial Manufacture and Applications of Optically Active CompoundsA. N. Collins, Gary Sheldrake, J. Crosby This second volume of Chirality in Industry contains new case histories from a wide range of contributors from industry or with strong industrial connections. While it is intended that the new volume will stand on its own, Volumes I and II taken together present an up-to-date and comprehensive picture of the technologies required to produce optically active compounds on a multi-kilogramme to high tonnage scale as well as illustrating the breadth of application of these technologies; the pharmaceuticals, agrochemicals, electronics, food, flavour and fragrance industries are all represented. Chirality in Industry II
The chiral infrastructure is now largely in place and there is no reason why large-scale production should not be possible for even moderately priced single enantiomer products. The successful industrial application of chiral chemistry depends on the integration of a range of supporting technologies and there are many examples in this volume of how widely the industrial practitioner must cast the net to achieve practical production methods. As with Volume I, this new volume is of particular interest to those professionally involved in the scale-up processes for single enantiomers. However, students and researchers involved in a more academic pursuit of optical activity will also benefit from some of the facets of large-scale thinking. An economic solution is still most likely to be a simple, elegant solution. |
Contents
Regulatory Aspects | 11 |
Synthesis of Enantiomerically Pure Nucleosides | 41 |
Rational Design in Resolutions | 81 |
Crystal Science Techniques in the Manufacture of Chiral Compounds | 119 |
Membrane Separations in the Production | 157 |
Four Case Studies in the Development of Biotransformation | 183 |
Developments in | 207 |
Development of a Fullscale Process for a Chiral Pyrrolidine | 225 |
Synthesis and Applications of Chiral Liquid Crystals | 263 |
Biotransformation in the Production of LCarnitine | 287 |
Asymmetric Hydrocyanation of Vinylarenes | 309 |
Enantioselective Protonation in Fragrance Synthesis | 335 |
a Manufacturing Process Involving a Double Inversion | 353 |
Two Case Studies | 381 |
403 | |
Development of a Multistage Chemical | 245 |
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Chirality in Industry II: Developments in the Commercial Manufacture and ... A. N. Collins,Gary Sheldrake,J. Crosby No preview available - 1998 |