A Historical Perspective on Evidence-Based ImmunologyA Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights. The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells.
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Contents
| 1 | |
| 9 | |
| 21 | |
| 31 | |
| 39 | |
6 The Clonal Selection Theory of Antibody Formation | 47 |
7 Plasma Cells Produce Antibody of a Single Specificity | 55 |
How the Immune System Avoids SelfDestruction | 61 |
23 T Lymphocyte Subpopulations | 197 |
From TS to TREG | 207 |
25 Intercellular Communication in the Immune System | 217 |
26 AntibodyMediated Effector Mechanisms | 227 |
27 TLymphocyteMediated Effector Mechanisms | 235 |
Natural Killer NK and Natural Killer T NKT Lymphocytes | 243 |
29 Role of Dendritic Cells in the Adaptive Immune Response | 253 |
30 The Mucosal Immune System and Secretory IgA | 261 |
9 The Thymus in Lymphocyte Maturation | 69 |
10 The Bursa of Fabricius in Lymphocyte Maturation | 75 |
11 Revealing the Structure of the Immunoglobulin Molecule | 83 |
12 Complement | 95 |
13 Antibody Production Requires ThymusDerived and Bone Marrow BursaDerived Lymphocyte Interactions | 105 |
Role of Adherent Cells | 113 |
15 Recognition Structures on Cells of the Innate Host Defense Mechanisms | 121 |
16 The Adaptive Immune Response and Histocompatibility Genes | 129 |
Identification of AntigenSpecific Receptors | 141 |
18 Generation of Diversity in the Adaptive Immune Response | 151 |
19 B Lymphocyte Activation | 159 |
20 Activation of T Lymphocytes and MHC Restriction | 169 |
21 Development of Tolerance to Self in B Lymphocytes | 181 |
22 Development of Tolerance to Self in T Lymphocytes | 189 |
31 Disorders of the Innate Host Defenses | 269 |
32 Defects in the Adaptive Immune Response Leading to Recurrent Infections | 277 |
33 Pathologies Resulting from Aberrant Immune Responses | 287 |
34 Immune Responses Directed Against Self | 299 |
35 Lymphoproliferative Diseases | 309 |
36 Transplantation Immunology | 317 |
37 Tumor Immunology | 329 |
38 Therapies That Manipulate Host Defense Mechanisms | 341 |
39 Techniques to Detect and Quantify Host Defenses | 353 |
40 The Future of Immunology | 365 |
| 373 | |
Back Cover | 381 |
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Common terms and phrases
activation adaptive immune response adaptive immune system allogeneic animals anti antibodies specific antibody formation antibody production antibody response antigen assay autoimmune bacteria binding bone marrow cancer CD4+ cell surface Chapter clinical clonal selection theory clones colleagues complement complement system coworkers cultures cytes cytokines cytotoxic cytotoxic T lymphocytes demonstrated dendritic cells described detected differentiation disease factor function gamma globulin genes coding genetic globulin guinea pigs histocompatibility human hypersensitivity immu immune system immunoglobulin Immunol immunological induce inhibit initial injected innate host defenses interaction investigators isolated isotype lymph nodes lympho lymphoid macrophages mechanisms mice molecular molecules monoclonal antibodies mouse myeloma NK lymphocytes patients peripheral blood phagocytic phagocytosis phocytes plasma cells produce antibodies proteins rabbits reaction receptors Research role secretion serum skin small lymphocytes spleen spleen cells SRBC strain studies synthesize thoracic duct thymectomized thymus tion tissue transplantation tumor University vaccine virus vitro