OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Notes for Analysis and Evaluation of Chronic Toxicity and Carcinogenicity StudiesOECD Publishing, Dec 12, 2002 - 112 pages These Guidance Notes outline core concepts in order to obviate the need to consult large numbers of text books, while still pointing the reader to sources of more detailed or specific information. They are intended to complement OECD Test Guidelines and other OECD publications, including Guidance for Industry Data Submissions and Guidance for Country Data Review Reports on Plant Protection Products and their Active Substances – Monograph Guidance |
Other editions - View all
OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and ... OECD No preview available - 2002 |
Common terms and phrases
activity adverse aminotransferase and/or bilirubin biological significance blood body weight cancer carcinogenesis carcinogenicity carcinogenicity studies cause cell changes chronic toxicity clinical chemistry concentration concurrent control correlate count Derelanko diet dietary dose selection dose–response relationship end-points enzyme erythrocyte experimental exposure factors food consumption Gamma-glutamyl transferase genotoxicity Guidance Document Haematocrit haematology haemoglobin hazard histopathology historical control data human IARC incidence increased inhalation intake interim sacrifice interpretation IPCS Environmental Health judgement key events kidney laboratory animals lesions levels liver Mean corpuscular Mean corpuscular volume metabolism mg/kg bw/d mice mode of action Mohr neoplasms NOEL or NOAEL observed OECD OECD Test Guidelines oncogenic OPPTS organ weight parameters pathology Pesticide platelet postulated mode potential ppm males rats regulatory relevant renal response risk assessment rodents scientific serum species spontaneous statistically significant termination test chemical test substance thyroid tissue toxicity studies toxicokinetics toxicology toxicology studies treatment-related tumours urinalysis urinary bladder