Adrenaline and the Inner World: An Introduction to Scientific Integrative Medicine

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JHU Press, Mar 15, 2006 - Self-Help - 328 pages

This accessible work is the first in more than seventy-five years to discuss the many roles of adrenaline in regulating the "inner world" of the body. David S. Goldstein, an international authority and award-winning teacher, introduces new concepts concerning the nature of stress and distress across the body's regulatory systems. Discussing how the body's stress systems are coordinated, and how stress, by means of adrenaline, may affect the development, manifestations, and outcomes of chronic diseases, Goldstein challenges researchers and clinicians to use scientific integrative medicine to develop new ways to treat, prevent, and palliate disease.

Goldstein explains why a former attorney general with Parkinson disease has a tendency to faint, why young astronauts in excellent physical shape cannot stand up when reexposed to Earth's gravity, why professional football players can collapse and die of heat shock during summer training camp, and why baseball players spit so much.

Adrenaline and the Inner World is designed to supplement academic coursework in psychology, psychiatry, endocrinology, cardiology, complementary and alternative medicine, physiology, and biochemistry. It includes an extensive glossary.

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Contents

Distress versus the General Adaptation Syndrome
150
Fight Isnt Flight
151
The Nose of God
158
StressToons
160
Stress in Evolutionary Perspective
164
Darwin and Ethology
169
The Price of Complexity Is Eternal Stress
172
Primitive Specificity
176

Rules of the Game
21
Same Difference
27
The AllDay Sucker
29
The Automatic Nervous System
30
Transformers
35
Good Housekeeping
40
The Hot Line
45
The Arbiters of the Inner World
57
On the Risk of Being a Physicians Son
58
Whats in a Name?
59
Catecholamines Look Like Cats
62
Adrenalines Effects on the Body
64
Neuronal Soda Pop
79
The Getaway Car Analogy
91
The Atavistic Catecholamine
93
First I Secreted a Hell of a Lot of Adrenaline
95
A PlayDoh Model of the Brain
101
The Nobel Chemicals
103
The Rest of the Cast
106
The Axis Powers
107
The Water Works and Kosher Pickle Treatment
110
Salt Sense
113
Your Own Brand of Morphine
115
Cytokines
117
Sex
118
Leptin
119
Stress as a Scientific Idea
121
Stress Response Patterns
129
Distress
141
Biblical Lie Detection
148
Dysautonomias
181
The MindBody Problem
182
Primary versus Secondary Dysautonomias
184
Secondary Dysautonomias
185
Primary Dysautonomias
194
Tests for Dysautonomias
207
Physiological Tests
209
Neuropharmacological Tests
215
Neurochemical Tests
220
Neuroimaging Tests
222
Treatments for Dysautonomias
224
Drug Treatments
229
Drugs and the Family
235
Legal Addictions
236
Cocaine
240
Morphine
242
You Arent What You Eat Luckily
243
The Future Scientific Integrative Medicine
247
Return of the Getaway Car
248
Allostatic Load for People Who Hate Snakes
250
The Dialectic
254
Darwinian Medicine
259
Tactics and Strategies of Scientific Integrative Medicine
263
What How and Why
266
Conclusion
269
Glossary
271
References
293
Index
295
Copyright

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Page 75 - and thy staff they comfort me. Thou prepares! a table before me in the presence
Page 50 - and bronchial Bronchial glands Stomach Motility and tone Sphincters Secretion Intestine Motility and tone Sphincters Secretion Gallbladder Kidney Urinary bladder Detrusor Trigone and sphincter Ureter Motility and tone Uterus Penis Skin Pilomotor muscles Sweat glands
Page 71 - Anger and joy are from the first exciting emotions, and they naturally lead, more especially the former, to energetic movements, which react on the heart and this again on the brain
Page 75 - of the shadow of death, I fear no evil: for thou art with me; thy rod and thy staff they comfort me. Thou prepares! a table before me in the presence
Page 71 - The excited brain gives strength to the muscles, and at the same time energy to the will
Page 85 - the synapsing sympathetic fibre, the function of which is to receive and transform the nervous impulse. Adrenalin(e) might then be a chemical stimulant liberated on each occasion when the impulse arrives at the periphery." It took until the early 1920s for experimental proof of this concept to emerge, and the scientist who provided that proof, Otto Loewi, received a Nobel Prize in 1936 for his discovery of the first neurotransmitter,
Page 261 - looks you have given me when I know you have been miserably uncomfortable." In sum then, we have someone with an early abhorrence of blood and operations, repeated bouts of trembling,
Page 123 - selection. As he wrote in The Wisdom of the Body, "The perfection of the process of holding a stable state in spite of extensive shifts of outer circumstance is not a special gift bestowed upon the highest organisms but is the consequence of a gradual evolution" (Cannon, 1939). Specifically, Cannon taught that the "sympathicoadrenal system" evolved to help maintain homeostasis in emergencies, such as traumatic hemorrhage, exercise to exhaustion, and

About the author (2006)

David S. Goldstein, M.D., Ph.D., is an attending physician at the Clinical Center, National Institutes of Health, and a senior investigator at the National Institute of Neurological Disorders and Stroke.

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