Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological TargetsReductionism to cellular and molecular mechanisms is one of the cornerstones of modern toxicology, forming the basis for a better understanding of individual toxic effects, and providing an important tool for human risk assessment. Mechanistic Toxicology is a timely textbook that provides an introduction to this important, but often neglected, area within the toxicological sciences. This book gives new insights into the processes and mechanisms underlying the toxicity of chemicals and explains how foreign compounds (drugs, environmental pollutants, industrial chemicals) exert their potentially damaging effects on cells and tissues. Features include: *an extensive number of illustrations, tables and photographs *summaries of the main learning points *question and answer reviews at the end of each chapter Mechanistic Toxicology incorporates recent advances in molecular biology and develops concepts for the reader in a logical way. It also illustrates, using many examples and complementary background information, how a better understanding of these mechanistic pathways helps in estimating potential risk to human health. Ideal for use in undergraduate and graduate classes of pharma-toxicology and environmental toxicology, Mechanistic Toxicology is also a valuable reference for any other readers interested in this subject. |
Contents
LXX | 145 |
150 | |
LXXIV | 151 |
LXXV | 152 |
LXXVI | 155 |
LXXVII | 158 |
LXXVIII | 160 |
LXXIX | 162 |
XIV | 25 |
30 | |
XVI | 32 |
XVIII | 34 |
XIX | 37 |
XX | 40 |
XXII | 43 |
XXIII | 45 |
50 | |
XXV | 51 |
XXVI | 52 |
XXVII | 57 |
XXIX | 59 |
XXX | 61 |
XXXI | 63 |
XXXII | 65 |
XXXIII | 66 |
XXXIV | 67 |
XXXV | 68 |
XXXVI | 70 |
XXXVII | 71 |
XXXVIII | 72 |
XXXIX | 74 |
XL | 75 |
XLI | 76 |
XLII | 81 |
XLIII | 85 |
XLVI | 86 |
90 | |
XLIX | 90 |
L | 91 |
LI | 96 |
LII | 99 |
LIII | 102 |
LIV | 106 |
LV | 108 |
LVI | 109 |
LVII | 112 |
LVIII | 115 |
LIX | 118 |
LX | 119 |
LXI | 121 |
LXII | 122 |
LXIII | 124 |
LXIV | 126 |
LXV | 129 |
LXVII | 142 |
LXIX | 143 |
LXXX | 164 |
169 | |
LXXXII | 170 |
LXXXIII | 171 |
LXXXIV | 173 |
LXXXV | 175 |
181 | |
LXXXIX | 183 |
XC | 184 |
XCI | 186 |
XCIII | 189 |
XCIV | 193 |
XCV | 196 |
XCVI | 197 |
204 | |
XCIX | 205 |
C | 209 |
CI | 211 |
CII | 215 |
CIII | 217 |
CIV | 223 |
CV | 229 |
CVI | 231 |
CVII | 233 |
236 | |
CIX | 241 |
244 | |
CXII | 245 |
CXIII | 246 |
CXIV | 250 |
CXV | 252 |
CXVI | 255 |
CXVII | 256 |
CXVIII | 259 |
CXIX | 268 |
CXXI | 269 |
CXXII | 271 |
274 | |
CXXVI | 277 |
CXXVII | 279 |
CXXVIII | 282 |
CXXIX | 283 |
CXXXI | 287 |
CXXXIII | 293 |
CXXXIV | 296 |
CXXXV | 302 |
Other editions - View all
Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt ... Urs A. Boelsterli No preview available - 2017 |
Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt ... Urs A. Boelsterli No preview available - 2002 |
Common terms and phrases
acetaminophen activation acyl glucuronide adducts anion antioxidant APAP apoptosis B-oxidation bile bioactivation biological Ca2+ carcinogen caspases cause cell cycle cell death cell injury cell proliferation cellular chemical compounds concentrations conjugate covalent binding cytochrome cytokines cytosol damage diclofenac dose drug effects electron electrophilic enzyme estrogen example exposure expression fatty acids Figure formation function genes glucuronide glutathione halothane hapten hepatic hepatocytes hepatotoxicity humans immune inactivation increased induced inhibition interactions intermediate intracellular involved kidney kinase Kupffer cells levels ligand liver liver injury lung macrophages mechanistic mediated membrane metabolism metabolites mice microcystins mitochondrial molecular mechanisms molecules MPTP necrosis nephrotoxicity normal organs oxidative stress oxygen P-glycoprotein pathways peptide peroxisome Pharmacol plasma potential production prooxidant proteins radical reactions reactive metabolites receptor redox cycling regulated response result role signal specific substrate superoxide target TCDD thalidomide tissue toxicity Toxicol toxicological transcription factors transport tumor xenobiotic-induced xenobiotics
References to this book
Phase II Conjugation Enzymes and Transport Systems, Volume 400 Helmut Sies,Lester Packer Limited preview - 2005 |