Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets

Front Cover
CRC Press, Oct 24, 2002 - Medical - 344 pages
Reductionism to cellular and molecular mechanisms is one of the cornerstones of modern toxicology, forming the basis for a better understanding of individual toxic effects, and providing an important tool for human risk assessment. Mechanistic Toxicology is a timely textbook that provides an introduction to this important, but often neglected, area within the toxicological sciences. This book gives new insights into the processes and mechanisms underlying the toxicity of chemicals and explains how foreign compounds (drugs, environmental pollutants, industrial chemicals) exert their potentially damaging effects on cells and tissues.

Features include:
*an extensive number of illustrations, tables and photographs
*summaries of the main learning points
*question and answer reviews at the end of each chapter

Mechanistic Toxicology incorporates recent advances in molecular biology and develops concepts for the reader in a logical way. It also illustrates, using many examples and complementary background information, how a better understanding of these mechanistic pathways helps in estimating potential risk to human health. Ideal for use in undergraduate and graduate classes of pharma-toxicology and environmental toxicology, Mechanistic Toxicology is also a valuable reference for any other readers interested in this subject.
 

Contents

IV
1
V
5
VII
7
VIII
15
IX
16
X
17
XI
19
XII
23
LXX
145
LXXII
150
LXXIV
151
LXXV
152
LXXVI
155
LXXVII
158
LXXVIII
160
LXXIX
162

XIV
25
XV
30
XVI
32
XVIII
34
XIX
37
XX
40
XXII
43
XXIII
45
XXIV
50
XXV
51
XXVI
52
XXVII
57
XXIX
59
XXX
61
XXXI
63
XXXII
65
XXXIII
66
XXXIV
67
XXXV
68
XXXVI
70
XXXVII
71
XXXVIII
72
XXXIX
74
XL
75
XLI
76
XLII
81
XLIII
85
XLVI
86
XLVII
90
XLIX
90
L
91
LI
96
LII
99
LIII
102
LIV
106
LV
108
LVI
109
LVII
112
LVIII
115
LIX
118
LX
119
LXI
121
LXII
122
LXIII
124
LXIV
126
LXV
129
LXVII
142
LXIX
143
LXXX
164
LXXXI
169
LXXXII
170
LXXXIII
171
LXXXIV
173
LXXXV
175
LXXXVI
181
LXXXIX
183
XC
184
XCI
186
XCIII
189
XCIV
193
XCV
196
XCVI
197
XCVII
204
XCIX
205
C
209
CI
211
CII
215
CIII
217
CIV
223
CV
229
CVI
231
CVII
233
CVIII
236
CIX
241
CXI
244
CXII
245
CXIII
246
CXIV
250
CXV
252
CXVI
255
CXVII
256
CXVIII
259
CXIX
268
CXXI
269
CXXII
271
CXXIII
274
CXXVI
277
CXXVII
279
CXXVIII
282
CXXIX
283
CXXXI
287
CXXXIII
293
CXXXIV
296
CXXXV
302
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