Studies in Natural Products Chemistry: Stereoselective Synthesis (Part K)

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Elsevier, May 1, 1996 - Science - 1108 pages
In Volume 18 of this well-established series, Professor Atta-ur-Rahman again brings together the work of several of the world's leading authorities in organic chemistry. Their contributions demonstrate the rapid, ongoing development of this field by illustrating many of the latest advances in synthetic methods, total synthesis, structure determination, biosynthetic pathways, and biological activity.

The opening chapter presents an overview of strategies for the synthesis of several classes of natural products with an emphasis on complex polycyclic systems. Subsequent chapters discuss the synthesis of specific classes of compounds, including morphine, polyketides, acetogenins, nonactic acid derivatives, complex spirocyclic ethers, -lactam and pyridone derivatives, inositol phosphates, sphingolipids, brassinosteroids, Hernandia lignans, and dimeric steroidal pyrazine alkaloids. Finally, the ever stronger links between chemistry and biology are reinforced by chapters on the origin and function of secondary metabolites, bioactive conformations of gastrin hormones, and immunochemistry.
 

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Contents

Chapter 2 A Historical Perspective of Morphine Synthesis
43
Chapter 3 New Developments in the Synthesis of Polyketides and of Chiral Methyl Groups
155
A New Class of Bioactive Polyketides
193
Chapter 5 The Synthesis of Nonactic Acid Its Derivatives and Nonactin itself
229
Chapter 6 Total Synthesis of Bioactive Natural Spiroethers Tautomycin and Oscillatoxin D
269
Chapter 7 AzaAnnulation of Enamine Related Substrates with αβUnsaturated Carboxylate Derivatives as a Route to the Selective Synthesis of δLacta...
315
Chapter 8 Selective Reactions and Total Synthesis of Inositol Phosphates
391
Chapter 9 Synthesis of Phytosphingolipids
457
Chapter 13 Bioactive Gymnemic Acids and Congeners from Gymnema sylvestre
649
Chapter 14 Theory of the Origin Function and Evolution Secondary Metabolites
677
Chapter 15 The Celastraceae from Latin America Chemistry and Biological Activity
739
Chapter 16 Structural Chemistry of Glycolipids from Fungi and Protozoa
785
Chapter 17 Potential Bioactive Conformations of Hormones of the Gastrin Family
819
The Dimeric SteroidPyrazine Marine Alkaloids
875
Chapter 19 Human IgGl HingeFragment as a Core Structure for Immunogens
907
A Comprehensive Review
971

Chapter 10 New Developments in Brassinosteroid Research
495
Chapter 11 Structure Elucidation and Synthesis of the Lignans from the Seeds of Hernandia ovigera L
551
Chapter 12 Studies on the Absolute Configuration of Some Liverwort Sesquiterpenoids
607

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About the author (1996)

Atta-ur-Rahman, Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan, was the Pakistan Federal Minister for Science and Technology (2000-2002), Federal Minister of Education (2002), and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. He is a Fellow of the Royal Society of London (FRS) and an UNESCO Science Laureate. He is a leading scientist with more than 930 publications in several fields of organic chemistry.

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