The Endocannabinoidome: The World of Endocannabinoids and Related MediatorsVincenzo Di Marzo, Jenny Wang The Endocannabinoidome: The World of Endocannabinoids and Related Mediators is dedicated to the latest research and studies on endocannabinoids and cannabinoid receptors to illustrate their important role in the discovery of new, endocannabinoid-related, lipid mediators. Written by leading experts across different disciplines, this book focuses on the biochemical and anlayticial aspects of novel lipid signals, their pharmacological activities and their potential utilization for the development of new and effective therapeutic strategies. The first book of its kind, The Endocannabinoidome is a meaningful reference for all those involved in experimental efforts to further the development of this field. - Explores the novel and exciting aspects of several endocannabinoid-like molecules for which researchers are still seeking a function - Discusses the novel metabolic pathways for endocannabinoids in order to explain the failure of some clinical trials with inhibitors of more conventional metabolic pathways - Incorporates pharmacology, biochemistry and potential clinical applications to provide researchers with a complete look at endocannabinoids |
Contents
| 1 | |
| 15 | |
Ubiquitous Endogenous Cannabimimetic Lipids That Are in the Right Place at the Right Time | 33 |
Chapter 4 Oxidative Metabolites of Endocannabinoids Formed by Cyclooxygenase2 | 49 |
From Synthetic Pharmacological Tools to Endogenous Multitarget Mediators | 67 |
Chapter 6 The Pharmacology of Prostaglandin F2α Ethanolamide and Bimatoprost Reveals a Unique Feedback Mechanism on Endocanna | 85 |
Chapter 7 Prostamide F2α Biosynthesizing Enzymes | 101 |
Chapter 8 Metabolic Enzymes for Endocannabinoids and EndocannabinoidLike Mediators | 111 |
Omics Approaches Applied to Endocannabinoids and EndocannabinoidLike Mediators | 137 |
Chapter 10 Common Receptors for EndocannabinoidLike Mediators and Plant Cannabinoids | 153 |
| 177 | |
Other editions - View all
The Endocannabinoidome: The World of Endocannabinoids and Related Mediators Vincenzo Di Marzo,Jenny Wang No preview available - 2014 |
Common terms and phrases
2-arachidonoylglycerol Acad Sci USA acid amidase acid amide hydrolase activity agonist anandamide antagonist arachidonic acid bimatoprost Biochem Biochim Biophys Acta Biol Chem biological biosynthesis Bisogno brain Ca2+ cannabidiol cannabinoid receptor cells channels compounds Cravatt BF DHEA DHEA and EPEA dopamine effects endocannabinoid system endocannabinoid-like enzyme esters ethanolamide FAAH FAAH inhibitor fatty acid fatty acid amide FP receptor glycerol human hydrolysis inflammatory inhibition levels ligands lipid lipidomics MAGL Marzo mediators metabolism metabolites mice molecular molecules mouse N-acyl amides N-acylethanolamines N-arachidonoyl NAAA nabinoid NAEs NAGly NAPE NAPE-PLD Natl Acad Sci neurons oxidative palmitoylethanolamide pathways peroxisome proliferator-activated peroxisome proliferator-activated receptor Petrocellis PG-EAs PG-Gs PGF synthase Pharmacol pharmacology phospholipase phytocannabinoids Piscitelli plasma potential PPARg PPARs precursor Proc Natl Acad prostaglandin prostamide F prostamide/PGF synthase prostanoid protein reductase role signaling studies targets tissues transient receptor potential TRPV1 Tsuboi vanilloid vitro vivo Wang Woodward DF


