The Endocannabinoidome: The World of Endocannabinoids and Related Mediators

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Vincenzo Di Marzo, Jenny Wang
Academic Press, Sep 18, 2014 - Medical - 208 pages

The Endocannabinoidome: The World of Endocannabinoids and Related Mediators is dedicated to the latest research and studies on endocannabinoids and cannabinoid receptors to illustrate their important role in the discovery of new, endocannabinoid-related, lipid mediators. Written by leading experts across different disciplines, this book focuses on the biochemical and anlayticial aspects of novel lipid signals, their pharmacological activities and their potential utilization for the development of new and effective therapeutic strategies. The first book of its kind, The Endocannabinoidome is a meaningful reference for all those involved in experimental efforts to further the development of this field.

  • Explores the novel and exciting aspects of several endocannabinoid-like molecules for which researchers are still seeking a function
  • Discusses the novel metabolic pathways for endocannabinoids in order to explain the failure of some clinical trials with inhibitors of more conventional metabolic pathways
  • Incorporates pharmacology, biochemistry and potential clinical applications to provide researchers with a complete look at endocannabinoids
 

Contents

Old Molecules New Targets
1
A Link Between Diet and Cellular Biology
15
Ubiquitous Endogenous Cannabimimetic Lipids That Are in the Right Place at the Right Time
33
Chapter 4 Oxidative Metabolites of Endocannabinoids Formed by Cyclooxygenase2
49
From Synthetic Pharmacological Tools to Endogenous Multitarget Mediators
67
Chapter 6 The Pharmacology of Prostaglandin F2α Ethanolamide and Bimatoprost Reveals a Unique Feedback Mechanism on Endocanna
85
Chapter 7 Prostamide F2α Biosynthesizing Enzymes
101
Chapter 8 Metabolic Enzymes for Endocannabinoids and EndocannabinoidLike Mediators
111
Omics Approaches Applied to Endocannabinoids and EndocannabinoidLike Mediators
137
Chapter 10 Common Receptors for EndocannabinoidLike Mediators and Plant Cannabinoids
153
Index
177
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About the author (2014)

Dr. Di Marzo has been invited to over 100 International conferences, including a plenary lecture at the Seventh International Conference on Eicosanoids and Other Bioactive Lipids in Cancer and Inflammation, in Nashville in October 2001, the Opening Lecture at the School of Neuroscience, held in Catania, July, 2003, a plenary lecture at the Italian Academy of Sciences (Academia Nazionale dei Lincei), in Rome, November 2004, a key note lecture at the 2nd Conference on Non-Mammalian Eicosanoids, Berlin, May 2006, plenary lectures at the 2nd and 3rd Gordon Conference on Cannabinoid function in the brain, Switzerland, 2007 and USA, 2009, a plenary lecture at the XIX National Meeting on Medicinal Chemistry in Verona, September 2008, and a plenary lecture at the 2012 International Conference of PAIN (IASP) held in Milan, August 28. He has been Co-chair at the 4th Gordon Conference on “Cannabinoid function in the brain”, Les Diablerets, Switzerland, May 2011.

Jenny W. Wang obtained a BS from Peking University in China, a MS from the University of California at Los Angeles (UCLA) in the USA, and a Ph.D. from the University of Aberdeen in the UK. Dr. Wang’s professional discipline includes biochemistry, molecular/cellular biology, and pharmacology with experience in anti-cancer, potassium channel, retinoid, and eicosanoid research. She gained extensive knowledge on RNA, DNA, protein, lipid, and assay development while working at City of Hope, California Institute of Technology, Beckman Instruments and Allergan Inc. Dr. Wang is a researcher with a passion in drug discovery. She is currently a Research Investigator on the fatty acid amides program and the team leader on prostamides for hair growth at Allergan, California, USA, where she particularly focuses on eicosanoid research. Her major current therapeutic interests are inflammation and hair growth. In addition to her own research, Dr. Wang enjoys the interaction with academic collaborators and contract research organizations. Dr. Wang is an author of 30 peer-reviewed publications, an inventor on 34 patents (3 granted, 18 published, 13 pending), and has been invited speaker/session chairman at various scientific meetings.

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