Paratuberculosis: Organism, Disease, Control

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Marcel A. Behr, Desmond M. Collins
CABI, 2010 - Medical - 375 pages
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This book discusses the history, prevalence, economic costs, disease control, diagnosis, vaccine development, aetiological agent, and control programmes of paratuberculosis in ruminants. Topics discussed are: history of paratuberculosis; prevalence and economics of infection of Mycobacterium avium subsp. paratuberculosis; epidemiology of Mycobacterium avium subsp. paratuberculosis; Mycobacterium avium subsp. paratuberculosis in animal-derived foods and environment; paratuberculosis and Crohn's disease; genetics of host susceptibility to paratuberculosis; Mycobacterium avium complex; Mycobacterium avium subsp. paratuberculosis genome, molecular genetics, proteome and antigens; host-pathogen interactions and intracellular survival of Mycobacterium avium subsp. paratuberculosis; comparative differences between the strains of Mycobacterium avium subsp. paratuberculosis; antibacterial agents against paratuberculosis; paratuberculosis in cattle, sheep, goats, deer, camelids, other ruminants and non-ruminant wildlife; experimental ruminant and small animal models of paratuberculosis; immunology of paratuberculosis infection and disease; cultivation of Mycobacterium avium subsp. paratuberculosis; diagnosis of paratuberculosis by PCR; immune-based diagnosis of paratuberculosis; strain characterization of Mycobacterium avium subsp. paratuberculosis; paratuberculosis control measures in Europe, USA and Australia; ruminant aspects of paratuberculosis vaccination; and development of new paratuberculosis vaccines. This book is intended for epidemiologists, veterinarians, farm owners and managers, wildlife practitioners, geneticists and students.
 

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Contents

1 History of Paratuberculosis
1
2 Global Prevalence and Economics of Infection with Mycobacterium avium subsp paratuberculosis in Ruminants
10
3 Epidemiology of Paratuberculosis
22
4 Mycobacterium avium subsp paratuberculosis in Animalderived Foods and the Environment
29
5 Paratuberculosis and Crohns Disease
40
6 Genetics of Host Susceptibility to Paratuberculosis
50
7 Mycobacterium avium Complex
60
8 Mycobacterium avium subsp paratuberculosis Genome
73
17 Paratuberculosis in Deer Camelids and Other Ruminants
179
18 Infection of Nonruminant Wildlife by Mycobacterium avium subsp paratuberculosis
188
19 Experimental Ruminant Models of Paratuberculosis
201
20 Experimental Small Animal Models of Paratuberculosis
223
21 Immunology of Paratuberculosis Infection and Disease
230
22 Cultivation of Mycobacterium avium subsp paratuberculosis
244
23 Diagnosis of Paratuberculosis by PCR
267
24 Immunebased Diagnosis of Paratuberculosis
284

9 Molecular Genetics of Mycobacterium avium subsp paratuberculosis
83
10 Proteome and Antigens of Mycobacterium avium subsp paratuberculosis
94
11 HostPathogen Interactions and Intracellular Survival of Mycobacterium avium subsp paratuberculosis
109
12 Comparative Differences between Strains of Mycobacterium avium subsp paratuberculosis
126
13 Mycobacterium avium subsp paratuberculosis and Antimicrobial Agents
138
14 Paratuberculosis in Cattle
144
15 Paratuberculosis in Sheep
157
16 Paratuberculosis in Goats
169
25 Strain Characterization of Mycobacterium avium subsp paratuberculosis
294
26 Paratuberculosis Control Measures in Europe
306
27 Paratuberculosis Control Measures in the USA
319
28 Paratuberculosis Control Measures in Australia
330
29 Ruminant Aspects of Paratuberculosis Vaccination
344
30 Development of New Paratuberculosis Vaccines
353
Index
369
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