Mobile Genetic ElementsDavid J. Sherratt Mobile genetic elements are present in all organisms. They are a major cause of spontaneous genetic change and are now exploited by geneticists as important tools for obtaining mutants, isolating genes, and for studying gene expression. The approach is comparative and the book addressestransposable elements as genetic tools, mechanisms that lead to genetic change, and how novel elements contribute to organism biology and evolution. |
Contents
Plasmids phages and episomes | 4 |
Genome reorganization as a biological process | 10 |
Mechanisms of DNA transposition | 18 |
Copyright | |
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alleles American Society amino acids analysis Bacteriol bacteriophage Berg and M. M. Biol Caenorhabditis elegans Cell chromosome cloned co-integrate Cold Spring Harbor contain copy number D. E. Berg deletion derivatives DNA sequences donor Drosophila melanogaster element insertions EMBO encoded enzyme Escherichia coli eukaryotic excision frequency genome germline host hybrid initial synapse integrase integration interactions intramolecular inverted repeats isolated M. M. Howe eds maize marker McClintock mechanism Mobile DNA mobile genetic elements molecular msDNA msDNA synthesis msDNA-RNA mutagenesis mutations myxobacteria Natl Acad Nucleic Acids Res operon phage phenotype plasmid population primer Proc protein reaction recombinase region replicative transposition res sites retrons retrotransposons retroviral reverse transcriptase RNase H selection site-specific recombination Society for Microbiology specific strains strand exchange structure substrates supercoiled synapse synapse topology target DNA template trans transcription transposable elements transposase transposon transposon ends vector vitro vivo wild-type xanthus