Medicinal Natural Products: A Biosynthetic ApproachMedicinal Natural Products, Second Edition is a comprehensive guide providing information on all classes of natural products in medicine. It builds upon fundamental chemical principles and demonstrates a unique integration of plant, microbial and animal natural products in one volume. The text guides the reader through a wealth of diverse natural metabolites used in medicine with sources, production methods, use as drugs and modes of action all extensively covered. Taking a chemistry based approach it combines traditional pharmacognosy with medicinal chemistry. The structure is user-friendly and includes the acclaimed grey boxes on groups of products and detailed mechanistic explanations. * Adopts a novel biosynthetic theme rather than a traditional descriptive approach * Includes extensive further reading at the end of the chapter * Thoroughly revised and updated to incorporate comprehensive coverage of plant, microbial and animal products * Includes the latest developments in the field * New material on genetic manipulation of biosynthetic pathways and non-mevalonate pathway to terpanoids * User-friendly format including extensive use of chemical schemes with annotated mechanistic explanations |
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Contents
| 1 | |
| 7 | |
| 30 | |
| 36 | |
| 47 | |
| 51 | |
| 58 | |
Macrolides and Polyethers | 92 |
Vitamin D | 257 |
Progestogens | 267 |
Alkaloids Derived from Lysine | 307 |
Alkaloids Derived from Tyrosine | 315 |
Phenethylisoquinoline Alkaloids | 341 |
Ergot Alkaloids | 368 |
Alkaloids Derived from Anthranilic Acid | 376 |
Purine Alkaloids | 394 |
Cyclization Through DielsAlder Reactions | 111 |
Further Reading | 117 |
Cinnamic Acids | 130 |
Benzoic Acids from C6C3 Compounds | 141 |
Styrylpyrones | 147 |
Isoflavonoids | 154 |
Further Reading | 164 |
Irregular Monoterpenes | 186 |
Cardioactive Glycosides | 241 |
PEPTIDES PROTEINS AND OTHER AMINO ACID DERIVATIVES | 405 |
Nonribosomal Peptide Biosynthesis | 421 |
Peptide Toxins | 433 |
Cyanogenic Glycosides | 455 |
Further Reading | 461 |
CARBOHYDRATES | 465 |
Index | 487 |
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Common terms and phrases
4th edn acetate acetyl-CoA acid Figure activity agents alcohol aldehyde aldol alkaloids alkylation allylic amino acid analogues antibiotics aromatic ring bacteria biosynthesis carbocation carbon carbonyl cation cell CH2OH chain Chem Chemical Technology Chemistry cholesterol cinnamic acid Claisen cleavage CO2H CO2H coenzyme compounds contain Continues)_ Continued cyclization decarboxylation derived diphosphate double bond drug Encyclopedia of Chemical enolization enzyme ester fatty acids formation function give glycosides H OH hemiacetal HO2C hormone hydrolysis hydroxylation inhibit intermediate involved lactone malonyl-CoA medicinal metabolism methyl molecules morphine NADPH Nat Prod Rep Natural Products nitrogen nucleophilic nucleophilic attack oestrogen OH OH OH oxidation oxygen pathway penicillins peptide phenol plants polyketide precursor produced prostaglandins protein proton reaction receptors reduction residues ring system Schiff base SCoA semi-synthetic SEnz sequence shikimate side-chain skeleton species stereochemistry steroid Streptomyces structures substrate synthetic terpenoid tion toxic treatment vitamin whilst
Popular passages
Page 118 - Perry, NB, van Klink, JW, Burgess, EJ and Parmenter, GA, 2000, Alkamide levels in Echinacea purpurea: effects of processing, drying and storage...
Page 118 - Shanklin. J., and Cahoon. EB 1998. Desaturation and related modifications of fatty acids. Annu. Rev. Plant Physiol. Plant Mol. Biol. 49: 61 1-641 Shashidhara.
Page 117 - Harwood, JL (1996). Recent advances in the biosynthesis of plant fatty acids.
Page 486 - Loewus FA (1999) Biosynthesis and metabolism of ascorbic acid in plants and of analogs of ascorbic acid in fungi.
Page 398 - TM 1995. Alkaloid biosynthesis - The basis for metabolic engineering of medicinal plants. Plant Cell, 7: 1059-1070; and, Kutchan, TM 2005.
Page 462 - Marahiel MA, Stachelhaus T and Mootz HD (1997) Modular peptide synthetases involved in nonribosomal peptide synthesis. Chem Rev 97, 2651-2673.

