Medicinal Natural Products: A Biosynthetic Approach

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John Wiley & Sons, Jan 3, 2002 - Medical - 507 pages
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Medicinal Natural Products, Second Edition is a comprehensive guide providing information on all classes of natural products in medicine. It builds upon fundamental chemical principles and demonstrates a unique integration of plant, microbial and animal natural products in one volume. The text guides the reader through a wealth of diverse natural metabolites used in medicine with sources, production methods, use as drugs and modes of action all extensively covered. Taking a chemistry based approach it combines traditional pharmacognosy with medicinal chemistry. The structure is user-friendly and includes the acclaimed grey boxes on groups of products and detailed mechanistic explanations.
* Adopts a novel biosynthetic theme rather than a traditional descriptive approach
* Includes extensive further reading at the end of the chapter
* Thoroughly revised and updated to incorporate comprehensive coverage of plant, microbial and animal products
* Includes the latest developments in the field
* New material on genetic manipulation of biosynthetic pathways and non-mevalonate pathway to terpanoids
* User-friendly format including extensive use of chemical schemes with annotated mechanistic explanations
 

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Contents

ABOUT THIS BOOK AND HOW TO USE
1
THE BUILDING BLOCKS AND CONSTRUCTION
7
Some Vitamins Associated with the Construction Mechanisms
30
Saturated Fatty Acids
36
Acetylenic Fatty Acids
47
Prostaglandins
51
Thromboxanes
58
Macrolides and Polyethers
92
Vitamin D
257
Progestogens
267
Alkaloids Derived from Lysine
307
Alkaloids Derived from Tyrosine
315
Phenethylisoquinoline Alkaloids
341
Ergot Alkaloids
368
Alkaloids Derived from Anthranilic Acid
376
Purine Alkaloids
394

Cyclization Through DielsAlder Reactions
111
Further Reading
117
Cinnamic Acids
130
Benzoic Acids from C6C3 Compounds
141
Styrylpyrones
147
Isoflavonoids
154
Further Reading
164
Irregular Monoterpenes
186
Cardioactive Glycosides
241
PEPTIDES PROTEINS AND OTHER AMINO ACID DERIVATIVES
405
Nonribosomal Peptide Biosynthesis
421
Peptide Toxins
433
Cyanogenic Glycosides
455
Further Reading
461
CARBOHYDRATES
465
Index
487
Copyright

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Page 486 - Loewus FA (1999) Biosynthesis and metabolism of ascorbic acid in plants and of analogs of ascorbic acid in fungi.
Page 462 - Marahiel MA, Stachelhaus T and Mootz HD (1997) Modular peptide synthetases involved in nonribosomal peptide synthesis. Chem Rev 97, 2651-2673.

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