Chirotechnology: Industrial Synthesis of Optically Active Compounds

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CRC Press, May 27, 1993 - Science - 423 pages
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This reference provides an introduction to the phenomenon of chirality and its importance in conjunction with biological activity and offers an easy-to-read examination of practical, industrially relevant methods for the synthesis of optically active compounds.;Furnishing hands-on guidelines for the development of economically viable synthetic compounds, Chirotechnology: explains optical isomerism and stereochemistry; gives a general overview of various methods of synthesis; supplies detailed explications of specific techniques, including fermentation, crystallization, the chirality pool, enzymatic methods, and catalytic asymmetric synthesis; illustrates and compares approaches with examples taken directly from industry such as the synthesis of pharmaceuticals, agrochemicals, flavours, and fragrances; and clarifies the importance of determining which approach to use for the synthesis of particular molecules.;With over 1100 literature citations, tables and figures, Chirotechnology is a reference for chemical engineers; industrial, organic and medicinal chemists; and bioprocess technologists, as well as a text for upper-level undergraduate, graduate and continuing-education students in these disciplines.

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Introduction to Optical Isomerism
Chirality and Biological Activity
Synthetic Methodology
Fermentation Processes
The Chirality Pool
Racemate Resolution via Crystallization
Enzymatic Transformations
Catalytic Asymmetric Synthesis
Comparing Different Approaches
Future Prospects
Glossary of Terms

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About the author (1993)

All three authors, Roger Arthur Sheldon, Isabel Arends, Ulf Hanefeld, are currently employed at the TU Delft. Their research is directed towards the development of atom-efficient, low-waste processes for the synthesis of high added value chemicals, such as pharmaceuticals and chiral intermediates. Within the framework of green chemistry the aim is to respond to the public need towards the 12 principles of green chemistry.

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