Chirotechnology: Industrial Synthesis of Optically Active Compounds
This reference provides an introduction to the phenomenon of chirality and its importance in conjunction with biological activity and offers an easy-to-read examination of practical, industrially relevant methods for the synthesis of optically active compounds.;Furnishing hands-on guidelines for the development of economically viable synthetic compounds, Chirotechnology: explains optical isomerism and stereochemistry; gives a general overview of various methods of synthesis; supplies detailed explications of specific techniques, including fermentation, crystallization, the chirality pool, enzymatic methods, and catalytic asymmetric synthesis; illustrates and compares approaches with examples taken directly from industry such as the synthesis of pharmaceuticals, agrochemicals, flavours, and fragrances; and clarifies the importance of determining which approach to use for the synthesis of particular molecules.;With over 1100 literature citations, tables and figures, Chirotechnology is a reference for chemical engineers; industrial, organic and medicinal chemists; and bioprocess technologists, as well as a text for upper-level undergraduate, graduate and continuing-education students in these disciplines.
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Introduction to Optical Isomerism
Chirality and Biological Activity
The Chirality Pool
Racemate Resolution via Crystallization
Catalytic Asymmetric Synthesis
Comparing Different Approaches
Glossary of Terms
achiral alcohol aldehydes amine amino acid antibiotics asymmetric catalysis asymmetric hydrogenation asymmetric synthesis asymmetric transformation atom beta-blockers Biocatalysts Biotechnol bonds captopril carbohydrates catalyst catalytic asymmetric synthesis cells CH2OH chapter Chem chemical chiral auxiliary chiral ligands chiral molecules chirality pool classical resolution cofactor commercially complex configuration conversion COOMe coworkers cyanohydrin dehydrogenase developed diastereomeric salts diastereomers drugs enantiomeric enantiomers enantioselective enantiospecific enantiotopic enzymatic enzymes ester esterase European Patent example fermentation Figure Fischer formation glucose groups herbicides HOOC hydrolysis industrial synthesis intermediate involves isomer kinetic resolution lipase method microbial microorganisms mixture Noyori OH OH OH olefins optical purity optically active optically pure Organic Synthesis oxidation penicillin precursor preferential crystallization prochiral protein pure enantiomer pyrethroids racemic reaction reagent reduction resolving agent rotation route Sharpless soluble solvent Stereochemistry stereogenic center structure substrate synthesis of optically synthetic synthons Tetrahedron Asymm Tetrahedron Lett yeast
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