Psychiatric Epidemiology: Searching for the Causes of Mental DisordersSearching for the causes of mental disorders is as exciting as it it complex. The relationship between pathophysiology and its overt manifestations is exceedingly intricate, and often the causes of a disorder are elusive at best. This book is an invaluable resource for anyone trying to track these causes, whether they be clinical researchers, public health practitioners, or psychiatric epidemiologists-in-training. Uniting theory and practice in very clear language, it makes a wonderful contribution to both epidemiologic and psychiatric research. Rather than attempting to review the descriptive epidemiology of mental disorders, this book gives much more dynamic exposition of the thinking and techniques used to establish it. Starting out by tracing the brief history of psychiatric epidemiology, the book describes the study of risk factors as causes of mental disorders. Subsequent sections discuss approaches to investigation of biologic, genetic, or social causes and the statistical analysis of study results. The book concludes by following some of the problems involved in the search for genetic causes of mental disorders, and more complex casual relationships. |
Contents
The Burden of Mental Illness | 5 |
The Arc of Epidemiology | 15 |
Searching for the Causes of Mental Disorders | 25 |
Part II Risk Factors as Causes of Mental Disorders | 33 |
Cohort Designs in Psychiatric Epidemiology | 91 |
Diversity of Cohort Studies | 108 |
A Thought Experiment | 129 |
What It Is and What Can Be Done | 138 |
Unequal Attrition under Different Types of FollowUp | 151 |
Differential Misclassification | 168 |
CaseControl Designs in Psychiatric Epidemiology | 181 |
Applications of the CaseControl Study | 192 |
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Common terms and phrases
adjustment allele Alzheimer's disease analysis approach ascertainment assessment association studies bias birth cohort body mass index case-control design causal partners chapter childhood clinical cohort study comorbid comorbid disorder compared compute confidence interval confounding context control group cosegregation defined depression developed diagnoses differential misclassification disease risk dystonia effect environment environmental Epidemiol estimate example exposed and unexposed exposure and disease exposure odds family history follow-up gene genetic causes genetic linkage genome Greenland identified individuals interaction intimacy problems investigators logistic regression marker matching maternal measure mental disorders methods natural experiment nested case-control study noncases null hypothesis observed odds ratio onset p-value PDSE percent potential prenatal prevalence psychiatric disorders psychiatric epidemiology Public Health registry regression relationship risk period risk ratio sample scenario schizophrenia schizophrenia spectrum disorder selection Shadish source population statistical study outcome survival analysis tion twin study underlying cohort unexposed groups validity variable York