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19th century aminoglycosides antibacterial antibiotic attack antibiotic resistance ANTIBIOTICS IN PERSPECTIVE antimicrobial agents bacilli bacterial cell wall bacteriology become resistant Beit Chair beta-lactamases broth Cape Town cell anatomy cell wall chemical chemotherapy circumvent the action clinical cocci compounds conjugation decolourisation step Department destroying discovery dissolved certain bacteria Domagk enzymes Fleming Fleming's Florey and Chain FORDER M.B. genetic material Gram Gram-negative organisms Gram-positive organisms group of organisms hospital Howard Florey inactivate Lactam Leeuwenhoek lysozyme M.MED magic bullet Medical Microbiology Medical School medicine microbes microscope molecules natron Oxford group patient Paul Ehrlich penicillin to treat penicillins and cephalosporins Penicillium notatum peptidoglycan component peptidoglycan layer physician plasmid promoters in animal Prontosil proteins resistance genes Salvarsan Scientific American sexually transmitted disease staphylococci streptococci streptomycin substance sulphonamides sulphur drug temporary grandstand theory of disease therapeutic therapy transmitted disease gonorrhoea transposon true antibiotic University of Cape Virology Wernher and Beit wonder drugs