Nucleotide Analogues as Antiviral AgentsJohn C. Martin, American Chemical Society. Division of Carbohydrate Chemistry, American Chemical Society. Division of Medicinal Chemistry Largely in response to the AIDS epidemic, the amount of research directed toward the discovery of antiviral agents has greatly expanded. This new volume focuses on the potential of nucleotides to exert potent in vivo antiviral effects. It presents the findings of an international group of scientists who are carrying out research at the forefront of the nucleotide drug design. Twelve chapters describe many new concepts and results, much of which has been previously unpublished. This book assembles a valuable collection of information, offering insight into this increasingly important research topic. |
Contents
Synthesis of Acyclonucleoside Phosphonates for Evaluation | 17 |
Structural Requirements for Enzymatic Activation | 35 |
Phosphonylmethyl Ethers of Nucleosides and Their Acyclic | 51 |
Copyright | |
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Common terms and phrases
2-aminopurine 3-deazaneplanocin Acad acid actinomycin D acyclic acyclonucleoside acyclovir adenine adenosine Agents Chemother alkyl Antimicrob antiviral activity antiviral agents antiviral effect assay AZT-P-ddA Biochem Biol cellular Chem Chemical Cheng Clercq compounds concentration CPE-C cytomegalovirus ddF-ara-A DHPG diethyl dimers diphosphate DNA polymerase DNA synthesis DNA viruses dose drug efficacy enzyme ester evaluation ganciclovir glycoproteins glycosylation guanine H₂N herpes simplex virus Holư HPMPA HPMPC HPMPG inhibition inhibitors isomer linkage methyl methylphosphonate mg/kg mg/kg/day mice moiety molecular murine nucleotide analogues OH OH oligomers oligonucleotide analogues oligonucleotides oligosaccharides phosphate phosphonate phosphonylmethyl ether phosphorothioate phosphorylation PME-derivatives PMEA PMEG potent protein synthesis purine reaction replication reverse transcriptase ribavirin 5'-sulfamate Rosenberg Scheme selective side chain Smee structural studies substrate activity Table therapeutic index thymidine kinase toxicity treatment triphosphate uninfected Vero cells viral DNA viral enzyme Virol vivo yield