Muscle RelaxantsThe Monographs in Anaesthesiology series is designed to enable the anaesthetist, and others in the health services field, to stay abreast of the changing trends, advances and innovations associated with the research and developments in this clinical discipline. This monograph is devoted to neuromuscular blocking agents. It reviews the present state of receptor research, pharmacokinetic modelling, monitoring, analytical technology and clinical use of the neuromuscular blocking agents. Clinicians, scientists engaged in fundamental or applied research and students at the start of clinical or research training should find this volume of particular use. |
Contents
The nicotinic acetylcholine receptor | 19 |
Chemical structures of neuromuscular blocking agents | 59 |
Some aspects of the physiology pharmacology and immunobiology of | 87 |
Copyright | |
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Common terms and phrases
AChR administration agonist Agoston Anaesth anaesthesia anaesthetic Analg Anesthesiology antagonism antagonists antibodies atracurium binding Biol blockade blood bromide cardiac cardiovascular choline clearance Clin clinical compounds curare d-tubocurarine decreased depolarizing disease drug concentration duration of action edrophonium effect elimination endplate excretion fazadinium function gallamine halothane hepatic histamine release HPLC increased infants infusion inhibition injection interaction intubation kinetics laudanosine liver Maelicke mechanism membrane metabolites method metocurine mg/kg Miller muscle relaxants muscular myasthenia gravis nAChR neonates neostigmine nerve stimulation neuro neuromuscular blocking agents neuromuscular blocking drugs neuromuscular junction neuromuscular transmission nicotinic acetylcholine receptor NMBA nondepolarizing onset pancuronium paralysis patients with renal pharmacokinetics Pharmacokinetics and pharmacodynamics Pharmacol pharmacology Physiol pipecuronium plasma concentration potency potential produce prolonged protein pyridostigmine recovery renal failure respiratory response sensitivity serum skeletal muscle structure studies subunits succinylcholine surgery suxamethonium tion tissue Torpedo train-of-four twitch vecuronium Viby-Mogensen volume of distribution Waud µg/l