Theories of Population Variation in Genes and GenomesThis textbook provides an authoritative introduction to both classical and coalescent approaches to population genetics. Written for graduate students and advanced undergraduates by one of the world's leading authorities in the field, the book focuses on the theoretical background of population genetics, while emphasizing the close interplay between theory and empiricism. Traditional topics such as genetic and phenotypic variation, mutation, migration, and linkage are covered and advanced by contemporary coalescent theory, which describes the genealogy of genes in a population, ultimately connecting them to a single common ancestor. Effects of selection, particularly genomic effects, are discussed with reference to molecular genetic variation. The book is designed for students of population genetics, bioinformatics, evolutionary biology, molecular evolution, and theoretical biology--as well as biologists, molecular biologists, breeders, biomathematicians, and biostatisticians.
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From inside the book
Results 1-5 of 18
... Infinite Alleles Model . . • 4.5.1 Heterozygosity in the infinite alleles model . 4.6 The Infinite Sites Model 4.7 Age of an Allele . . 71 72 74 75 76 77 80 84 86 . 87 91 93 95 99 100 . 104 4.8 Numerical Simulations 105 5 Migration 108 ...
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Contents
Genetics | 7 |
11 Genetic Variation | 9 |
Conservation of Variation | 21 |
21 Stochastic Fluctuations | 23 |
22 WrightFisher Process | 26 |
23 Gene Identity in a Finite Population | 31 |
24 Coalescence of Genes | 33 |
25 Characteristic Time Unit | 41 |
65 Recombination and Physical Distance | 177 |
Phenotypic Variation | 181 |
71 Quantitative Inheritance | 185 |
72 Kin Resemblance | 188 |
73 Inference on the Genotypic Variance | 195 |
74 Mapping of Quantitative Trait Loci | 202 |
Variation and Selection | 213 |
Effects of Selection | 216 |
26 Diffusion Approximation | 42 |
27 Morans Model | 50 |
Diploid Populations | 53 |
31 Random Mating | 54 |
32 Effective Population Size | 62 |
33 Genotypic Frequencies | 69 |
Mutation and Variation | 71 |
41 Mutation | 72 |
42 The TwoAllele Model | 77 |
43 Genealogy and Variation | 84 |
44 Mutation and Coalescence | 87 |
45 The Infinite Alleles Model | 95 |
46 The Infinite Sites Model | 100 |
47 Age of an Allele | 104 |
48 Numerical Simulations | 105 |
Migration | 108 |
51 Population Genetics of Migration | 109 |
52 Population Structure | 118 |
53 Genotypic Proportions | 133 |
Linkage | 139 |
61 The Karyotype | 141 |
62 Population Genetics of Linkage | 148 |
63 Linkage Equilibrium | 150 |
64 The Ancestral Recombination Graph | 161 |
81 Selection Components | 219 |
82 Viability Selection | 222 |
83 Selection on a Quantitative Character | 234 |
84 Mutation and Selection | 245 |
85 Stability of an Equilibrium | 248 |
86 The Coalescent and Selection | 255 |
Genomic Effects of Selection | 264 |
91 Multilocus Selection | 268 |
92 Selection Experiments in Drosophila | 279 |
93 Hitchhiking | 285 |
94 Inbreeding Depression | 291 |
95 Sweeps by Selection | 301 |
Population Structure | 309 |
101 Polymorphism | 310 |
102 Introgression | 320 |
103 Divergence of Populations | 338 |
Probability Theory and Statistics | 345 |
A2 Markov Chains | 355 |
A3 Continuous Random Variables | 359 |
Solutions to Exercises | 363 |
Bibliography | 383 |
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Other editions - View all
Theories of Population Variation in Genes and Genomes Freddy Bugge Christiansen Limited preview - 2014 |
Theories of Population Variation in Genes and Genomes Freddy Bugge Christiansen Limited preview - 2014 |