Altered Glycosylation in Tumor Cells: Proceedings of a Smith-Kline & French-Triton Biosciences-UCLA Symposium, Held in Keystone, Colorado, April 6-12, 1987Sen-itiroh Hakomori, Christopher L. Reading, Donald M. Marcus |
Contents
Glycolipid Antigen Expression | 1 |
Developmentally Regulated Expression of Cell Surface Carbohydrates During | 13 |
Detection of GD3 Ganglioside in Childhood Acute Lymphoblastic Leukemia With | 59 |
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Acad Sci USA activity adhesion alterations analysis antigens appear assay associated bands binding Biochem Biol Chem blood Cancer Cancer Res carbohydrate carcinoma cell lines cell surface changes chromatography colon containing culture decreased demonstrated described detected determined differentiation disease EC cells effect embryonic enzyme expression extracts Figure function GalTase ganglioside gels gene glycolipids glycophorin glycoproteins glycosylation growth Hakomori heparan sulfate heparan sulfate proteoglycan human increased incubated indicated inhibited isolated labeled Lane lectins leukemia levels major malignant medium membrane metastatic method migration molecular weight molecules monoclonal antibodies Natl Acad Sci Nature normal observed obtained oligosaccharides patients positive possible present Proc Natl protein proteoglycan purified recently receptor reported sequence serum showed shown sialic acids sialylated similar specific staining structures studies substrate sugar chains suggested Table tissues transformed treatment tumor cells type 2 chain University various