Dengue

Ch. 1. Dengue: overview and history. Host range. Geographical distribution. Disease burden and cost. History -- ch. 2. The infectious agent. Classification. Virion structure and morphology. Immune response induced by dengue viruses. Proteins encoded by the virus. Replication strategy. Conclusions -- ch. 3. Epidemiology. Introduction. Ecology of vector mosquitoes. Infectious disease epidemiology of Aedes aegypti-borne dengue. Sylvatic cycle of dengue transmission -- ch. 4. Resistance to infection. Introduction. Innate immunity. Antibody responses in natural infection. Vaccine development. Conclusion -- ch. 5. Clinical features of dengue. Introduction. Classification schemes. Clinical features. Differential diagnosis. Specific issues -- ch. 6. Management of dengue. Introduction. Management. Conclusions -- ch. 7. Pathogenesis: risk factors prior to infection. Introduction. Host factors. Viral factors. Discussion -- ch. 8. Elimination of infection. Introduction. Innate and adaptive cellular immune responses. Interferons. Natural killer cells. T lymphocytes. Naturally acquired versus vaccine-induced cellular immunity. Summary -- ch. 9. Pathophysiology. Introduction. Dengue infection model. Immunopathogenesis. Models of dengue pathophysiology -- ch. 10. Diagnosis of dengue virus infections. Introduction. antibody and virus patterns in dengue virus infection. Diagnostic pathway in patients with suspected acute dengue. Serological assays. Virus isolation and serotype identification. Immunohistochemistry. Genome-based assays. Future directions -- ch. 11. The control of dengue vectors. Introduction. Existing control methods; control of the aquatic stages. The environmental control of Ae. aegypti larval habitats. Larvicides used for the control of Ae. aegypti. The biological control of Ae. aegypti larvae. The use of fish predators against Ae. aegypti larvae. Predaceous mosquito larvae for the control of Ae. aegypti. The use of copepod predators. The use of Bti. Conclusions on the feasibility of larval control. Adulticidal control of Ae. aegypti. Space spray adulticiding for control of Ae. aegypti; the use of thermal fogs. Space spray adulticiding for control of Ae. aegypti; the use of ULV. Conclusions: what are the options? -- ch. 12. Biological control of dengue vectors: promises from the past -- ch. 13. Mosquito control: behavioral and community interventions. Conventional approaches to behavior change interventions. The emerging paradigm for behavioral interventions. Role of the community. Conclusions -- ch. 14. Controversies. I. The World Health Organization definition of dengue hemorrhagic fever is inadequate for clinical and epidemiological purposes. II. The association between dengue hemorrhagic fever and second dengue infections is simply coincidental. III. Dengue hemorrhagic fever is caused by virulent dengue viruses. IV. Dengue hemorrhagic fever is caused by an abnormal or accelerated T cell. V. Dengue hemorrhagic fever is caused by autoimmune phenomena triggered by a dengue viral infection