Seizures and EpilepsyThis second edition of Seizures and Epilepsy, written almost a quarter of a century after the ground-breaking first edition, is more than an update: it is a complete revision due to tremendous advances in the field. Our understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. According to the World Health Organization, epilepsy accounts for 1% of the global burden of disease, equivalent to breast cancer in women and lung cancer in men. Among primary disorders of the brain, it is equivalent to depression, dementia, and substance abuse. Singly authored by Jerome Engel, Jr, this must-read from 1989 reasserts itself as a modern classic comprehensive textbook covering a broad range of both basic and clinical epileptology. |
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abnormalities absence acid action activity antiseizure drugs appear areas associated behavioral brain cause cell cerebral changes Chapter chronic Classification clinical common Comprehensive Textbook condition considered continuous cortical determined diagnosis discharges disease disorders disturbances dose drugs early Edited effects Engel epilepsy epileptic seizures epileptiform epileptogenic et al factors Figure focal function genetic glucose half-life hippocampal human ictal identified important increased indicate induced initial interictal involve kindling later Lennox-Gastaut syndrome lesions levels limbic Lippincott Williams lobe epilepsy mechanisms medication models motor myoclonic Neurology neuronal normal occur onset partial patients patterns Pedley phenytoin Philadelphia postictal potential Press prevent progressive rare recorded referred reported require responsible result risk seen side sleep specific spikes status epilepticus stimulation structural studies suggest surgical symptoms syndrome Table temporal lobe therapy tion tonic-clonic treatment types usually Williams & Wilkins York zures