Operators and Promoters: The Story of Molecular Biology and Its CreatorsDuring the past four decades, molecular biology has dominated the life sciences. Curiously, no participant in this scientific revolution has previously attempted a book-length history of the development of this powerful science. Harrison ("Hatch") Echols provides such an account in Operators and Promoters. A gifted molecular biologist and talented raconteur, Echols relates the intellectual history of the most influential discoveries in molecular biology from his own experiences. Echols joins his vast knowledge of biology with personal interviews of the principal operators and promoters in the field to convey a captivating side of science--specifically, how the personalities of scientists and their competitive and collaborative relations affect new ideas and discoveries. The author reveals how logic and order often arise only in hindsight from the chaos of discovery; eventual solutions often come from experiments performed for entirely different reasons. Echols also shares his deep-seated feelings for the science itself, communicating his admiration, even awe, for the purity and simplicity with which life systems are organized. This gripping insider's account of the first fifty years of molecular biology ties together the biological questions with the scientific solutions of the people who established the field. It will appeal not only to students and those interested in the development of the discipline, but to anyone intrigued by the human side of science and the process of scientific inquiry and discovery. |
Contents
LXIX | 215 |
LXX | 219 |
LXXI | 220 |
LXXII | 221 |
LXXIII | 225 |
LXXIV | 226 |
LXXV | 228 |
LXXVI | 230 |
XII | 26 |
XIII | 32 |
XIV | 34 |
XV | 35 |
XVI | 36 |
XVII | 40 |
XVIII | 45 |
XIX | 49 |
XX | 56 |
XXI | 59 |
XXIII | 60 |
XXIV | 62 |
XXV | 63 |
XXVI | 64 |
XXVII | 65 |
XXVIII | 69 |
XXIX | 74 |
XXX | 77 |
XXXI | 81 |
XXXII | 82 |
XXXIII | 89 |
XXXIV | 96 |
XXXV | 101 |
XXXVI | 102 |
XXXVII | 103 |
XXXVIII | 105 |
XXXIX | 108 |
XL | 110 |
XLI | 113 |
XLII | 117 |
XLIII | 120 |
XLIV | 126 |
XLV | 129 |
XLVI | 131 |
XLVII | 132 |
XLVIII | 136 |
XLIX | 142 |
L | 146 |
LI | 148 |
LII | 153 |
LIII | 155 |
LIV | 158 |
LV | 162 |
LVI | 165 |
LVII | 166 |
LVIII | 167 |
LIX | 168 |
LX | 171 |
LXI | 172 |
LXII | 175 |
LXIII | 178 |
LXIV | 182 |
LXV | 189 |
LXVI | 199 |
LXVII | 203 |
LXVIII | 211 |
LXXVII | 231 |
LXXVIII | 233 |
LXXIX | 237 |
LXXX | 239 |
LXXXI | 242 |
LXXXII | 245 |
LXXXIII | 247 |
LXXXIV | 249 |
LXXXV | 251 |
LXXXVI | 254 |
LXXXVII | 256 |
LXXXVIII | 258 |
LXXXIX | 260 |
XC | 261 |
XCII | 262 |
XCIII | 266 |
XCIV | 268 |
XCV | 273 |
XCVII | 274 |
XCVIII | 275 |
XCIX | 277 |
C | 279 |
CI | 280 |
CII | 282 |
CIII | 283 |
CIV | 284 |
CV | 286 |
CVI | 290 |
CVIII | 293 |
CIX | 295 |
CX | 296 |
CXI | 297 |
CXII | 300 |
CXIII | 301 |
CXIV | 306 |
CXV | 308 |
CXVI | 312 |
CXVII | 314 |
CXVIII | 317 |
CXIX | 318 |
CXX | 319 |
CXXII | 321 |
CXXIII | 327 |
CXXIV | 333 |
CXXV | 338 |
CXXVI | 340 |
CXXVII | 344 |
CXXVIII | 347 |
CXXIX | 349 |
CXXX | 350 |
CXXXI | 352 |
CXXXII | 359 |
CXXXIII | 379 |
453 | |
458 | |
Other editions - View all
Operators and Promoters: The Story of Molecular Biology and Its Creators Harrison Echols,Carol Gross No preview available - 2001 |
Common terms and phrases
Acad activity amino acid assay B-galactosidase bacterial bacteriophage base base-pairing binding biochemical Biol cellular chain chemical chromosome cleavage Cold Spring Harbor complex DNA molecule DNA replication DNA sequence DNA strand DNA synthesis duplex DNA elongation Escherichia coli eukaryotic experiments extract factor Figure fragments function genetic genome heat shock proteins helicase hybridization identified induced infection initiation integration interactions isolated Jacob Kornberg Lac repressor lambda lysogenic mechanism molecular biology Monod mRNA mutations Natl nucleotides operon pathway peptide phage plasmid Pol III positive regulator precursor primer Proc produced promoter prophage protein synthesis purified radioactive reaction RecA region restriction enzyme ribosome RNA polymerase RNase RNase III rRNA segment single-strand DNA site-specific recombination specific splicing ẞ-galactosidase Steitz structure subunit tein termination tion transcription transposition transposon triplet tRNA tryptophan viral DNA virus viruses vitro