Annual Scientific Report

activity addition amino acid analysis antibodies antigen appears approach Associate binding Biol Biology cDNA cell lines cells cellular Center changes channel characterization chromosome cloned complex containing Continued Current cytoplasmic detected determine differentiation directed disease domain Duke University effect elements encoding enzyme experiments expression factor function gene gene expression genetic genomic growth hormone human identified important increase indicate induced initial Institute insulin insulin receptor interactions involved isolated kinase laboratory levels locus major mapping mechanisms mediated Medical Medicine membrane mice Michigan molecular molecules mouse mRNA mutations Nature neurons normal peptide Ph.D present Professor promoter protein recently receptor region regulation response role School selection sequence shown signal similar single specific stimulation structure studies subunit suggest surface tion tissue transcription transgenic understanding University virus York