Marks' Basic Medical Biochemistry: A Clinical Approach

Front Cover
Lippincott Williams & Wilkins, 2009 - Medical - 1011 pages

A best-selling core textbook for medical students taking medical biochemistry, Marks' Basic Medical Biochemistry links biochemical concepts to physiology and pathophysiology, using hypothetical patient vignettes to illustrate core concepts. Completely updated to include full-color art, expanded clinical notes, and bulleted end-of-chapter summaries, the revised Third Edition helps medical students understand the importance of the patient and bridges the gap between biochemistry, physiology, and clinical care.

A new companion Website will offer the fully searchable online text, an interactive question bank with 250 multiple-choice questions, animations depicting key biochemical processes, self-contained summaries of patients described in the book, and a comprehensive list of disorders discussed in the text, with relevant Website links. An image bank, containing all the images in the text, will be available to faculty.

 

Contents

Contents SECTION ONE Fuel Metabolism1
1
Metabolic Fuels and Dietary Components
3
The Fed or Absorptive State
22
Fasting31
31
SECTION TWO Chemical and Biologic Foundations of Biochemistry
41
Water Acids Bases and Buffers
43
Structures of the Major Compounds of the Body56
56
Amino Acids in Proteins73
73
Basic Concepts in the Regulation of Fuel Metabolism by Insulin Glucagon and Other Hormones
483
Digestion Absorption and Transport of Carbohydrates
499
Formation and Degradation of Glycogen
518
Pentose Phosphate Pathway Fructose and Galactose Metabolism
536
Synthesis of Glycosides Lactose Glycoproteins and Glycolipids
551
Gluconeogenesis and Maintenance of Blood Glucose Levels
566
SECTION SIX Lipid Metabolism
591
Digestion and Transport of Dietary Lipids
593

StructureFunction Relationships in Proteins92
92
Enzymes as Catalysts
116
Regulation of Enzymes
139
Relationship between Cell Biology and Biochemistry
156
Cell Signaling by Chemical Messengers
176
SECTION THREE Gene Expression and the Synthesis of Proteins
197
Structure of the Nucleic Acids
199
Synthesis of DNA216
216
Synthesis of RNA
233
Synthesis of Proteins254
254
Regulation of Gene Expression
271
Use of Recombinant DNA Techniques in Medicine
294
The Molecular Biology of Cancer
316
SECTION FOUR Fuel Oxidation and the Generation of ATP337
337
ATP and O2341
341
Tricarboxylic Acid Cycle361
361
Oxidative Phosphorylation and Mitochondrial Function
383
Glycosis
402
Oxidation of Fatty Acids and Ketone Bodies
421
Oxygen Toxicity and FreeRadical Injury443
443
Metabolism of Ethanol
464
SECTION FIVE Carbohydrate Metabolism
479
Synthesis of Fatty Acids Triacylglycerols and the Major Membrane Lipids
605
Cholesterol Absorption Synthesis Metabolism and Fate
634
Metabolism of the Eicosanoids
671
Integration of Carbohydrate and Lipid Metabolism
685
SECTION SEVEN Nitrogen Metabolism
701
Protein Digestion and Amino Acid Absorption
704
Urea Cycle715
715
Synthesis and Degradation of Amino Acids
731
Tetrahydrofolate Vitamin B12 and SAdenosylmethionine
751
Purine and Pyrimidine Metabolism
766
Intertissue Relationships in the Metabolism of Amino Acids
782
SECTION EIGHT Tissue Metabolism
803
Actions of Hormones That Regulate Fuel Metabolism
805
Biochemistry of Erythrocytes and Other Blood Cells
831
Blood Plasma Proteins Coagulation and Fibrinolysis
854
Liver Metabolism
870
Metabolism of Muscle at Rest and During Exercise
891
Metabolism of the Nervous System 911
911
The Extracellular Matrix and Connective Tissue
936
Answers to Review Questions
954
Index
979
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